Severe oligozoospermia in a young man with chronic myeloid leukemia on long-term treatment with imatinib started before puberty

被引：31

作者：

Mariani, Stefania

Basciani, Sabrina ^{[2
]}

Fabbri, Andrea ^{[3
]}

Agati, Luciano ^{[4
]}

Ulisse, Salvatore

Lubrano, Carla

Spera, Giovanni

Gnessi, Lucio ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Expt Med, Policlin Umberto I, I-00161 Rome, Italy

[2] Ist Ricovero & Cura Carattere Sci San Raffaele, Cardiovasc Res Unit, Tosinvest Sanita, Italy

[3] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy

[4] Univ Roma La Sapienza, Dept Cardiol, Rome, Italy

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 03期

关键词：

Imatinib; chronic myeloid leukemia; oligozoospermia; FERTILITY PRESERVATION; TYROSINE KINASES; C-KIT; GYNECOMASTIA; GROWTH; CRYOPRESERVATION; INHIBITION; CANCER; ONSET; PDGFR;

D O I：

10.1016/j.fertnstert.2010.08.060

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To report the effect of long-term treatment with the tyrosine kinase inhibitor imatinib started before the onset of puberty on semen parameters, bone mineral density, and hormone values. Design: Case report. Setting: University hospital. Patient(s): An 18-year-old man given treatment with imatinib for chronic myeloid leukemia. Intervention(s): Clinical, biochemical and dual-energy X-ray absorptiometry evaluations. Main Outcome Measure(s): Semen analysis, serum levels of gonadotropins, inhibin-B, and testosterone, bone mineral density, markers of skeletal homeostasis. Result(s): Semen analyses showed severe oligozoospermia after long-term administration of imatinib started before puberty. The inhibin-B/FSH ratio was reduced. A low bone mineral density for chronologic age was observed. Conclusion(s): This case study documents the potential risk of an impairment of semen parameters in patients undergoing a treatment with tyrosine kinase inhibitors before the complete maturation of the testis. (Fertil Steril (R) 2011;95:1120.e15-e17. (c) 2011 by American Society for Reproductive Medicine.)

引用

页码：1120.e15 / 1120.e17

页数：3

共 19 条

[1]

Andres MM., 2010, PAEDIAT CHILD HLTH, V20, P135, DOI [10.1016/j.paed.2009.10.004, DOI 10.1016/J.PAED.2009.10.004]

[2] CML in pregnancy and childhood [J].