Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes

被引：10
作者：
Ge, Feixiang [1 ]
Wang, Zetian [2 ]
Xi, Jianzhong Jeff [1 ]
机构：
[1] Peking Univ, Dept Biomed Engn, Coll Engn, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
[2] Peking Univ, Inst Microelect, Beijing 100871, Peoples R China
来源：
CELLS | 2020年 / 9卷 / 01期
关键词：
human pluripotent stem cell; cardiomyocytes; ventricular; cardiac tissue engineering; maturation; FUNCTIONAL MATURATION; PROMOTES MATURATION; HUMAN MYOCARDIUM; MODELS; TISSUE; DIFFERENTIATION; CARDIOMYOPATHY; MUSCLE; DRIVEN; RAT;
D O I：
10.3390/cells9010009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Heart diseases such as myocardial infarction and myocardial ischemia are paroxysmal and fatal in clinical practice. Cardiomyocytes (CMs) differentiated from human pluripotent stem cells provide a promising approach to myocardium regeneration therapy. Identifying the maturity level of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is currently the main challenge for pathophysiology and therapeutics. In this review, we describe current maturity indicators for cardiac microtissue and microdevice cultivation technologies that accelerate cardiac maturation. It may provide insights into regenerative medicine, drug cardiotoxicity testing, and preclinical safety testing.
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页数：9
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