Potentialities of Induced Pluripotent Stem (iPS) Cells for Treatment of Diseases

被引：8

作者：

Chakraborty, C. ^{[1
]}

Shah, K. D. ^{[2
]}

Cao, W. G. ^{[2
]}

Hsu, C. H. ^{[3
,4
]}

Wen, Z. H. ^{[3
,4
]}

Lin, C. S. ^{[3
,4
]}

机构：

[1] VIT Univ, Med Biotechnol Div, Sch Biosci & Technol, Vellore 632014, Tamil Nadu, India

[2] Chinese Acad Agr Sci, Inst Anim Sci & Vet Med Beijing, Beijing, Peoples R China

[3] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Coll Marine Sci, Kaohisung, Taiwan

[4] Natl Sun Yat Sen Univ, Div Marine Biotechnol, Asia Pacific Ocean Res Ctr, Kaohisung, Taiwan

来源：

CURRENT MOLECULAR MEDICINE | 2010年 / 10卷 / 08期

关键词：

Induced pluripotent stem (iPS) cell; disease-specific iPS cell lines; drug discovery and development; toxicological studies; personalized medicine; regenerative medicine; HUMAN FIBROBLASTS; MOUSE; GENERATION; EXPRESSION; INDUCTION; GENE; SOX2; KLF4; MYC; DIFFERENTIATION;

D O I：

10.2174/156652410793384178

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Induced pluripotent stem (iPS) cell research has been growing a new height throughout the world due to its potentialities in medical applications. We can explore several therapeutic applications through the iPS cell research. In this review, we have first discussed the development of iPS cells, reprogramming factors, and effectiveness of iPS cells. Then we have emphasized the potential applications of iPS cells in pharmaceutical and medical sectors, such as, study of cellular mechanisms for spectrum of disease entities, disease-specific iPS cell lines for drugs discovery and development, toxicological studies of drugs development, personalized medicine, and regenerative medicine.

引用

页码：756 / 762

页数：7

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