Targeting the protein-protein interactions of the HIV lifecycle

被引：18
|
作者：
Tavassoli, Ali [1 ]
机构：
[1] Univ Southampton, Southampton SO17 1BJ, Hants, England
来源：
CHEMICAL SOCIETY REVIEWS | 2011年 / 40卷 / 03期
关键词：
IMMUNODEFICIENCY-VIRUS TYPE-1; SMALL-MOLECULE INHIBITORS; DNA STRAND TRANSFER; REVERSE-TRANSCRIPTASE; ENVELOPE GLYCOPROTEIN; INTEGRASE INHIBITORS; SYNTHETIC PEPTIDE; RESISTANCE ALLELE; FUSION INHIBITOR; POTENT INHIBITOR;
D O I：
10.1039/c0cs00092b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), relies heavily on protein-protein interactions in almost every step of its lifecycle. Targeting these interactions, especially those between virus and host proteins, is increasingly viewed as an ideal avenue for the design and development of new therapeutics. In this tutorial review, we outline the lifecycle of HIV and describe some of the protein-protein interactions that control and regulate each step of this process, also detailing efforts to develop therapies that target these interactions.
引用
收藏
页码：1337 / 1346
页数：10
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