Affective symptoms and AT(N) biomarkers in mild cognitive impairment and Alzheimer's disease: A systematic literature review

被引：35
作者：
Banning, Leonie C. P. [1 ]
Ramakers, Inez H. G. B. [1 ]
Deckers, Kay [1 ]
Verhey, Frans R. J. [1 ]
Aalten, Pauline [1 ]
机构：
[1] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, POB 616, NL-6200 MD Maastricht, Netherlands
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2019年 / 107卷
关键词：
Affective symptoms; Biomarkers; Neurocognitive disorders; Mild cognitive impairment; Alzheimer's disease dementia; Systematic review; WHITE-MATTER HYPERINTENSITIES; CEREBROSPINAL-FLUID BIOMARKERS; TEMPORAL-LOBE ATROPHY; QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; NEUROPSYCHIATRIC SYMPTOMS; HIPPOCAMPAL VOLUME; ANXIETY SYMPTOMS; CSF BIOMARKERS; EARLY-STAGE;
D O I：
10.1016/j.neubiorev.2019.09.014
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Introduction: Alzheimer's disease (AD) biomarkers such as amyloid, p-tau and neuronal injury markers have been associated with affective symptoms in cognitively impaired individuals, but results are conflicting. Methods: CINAHL, Embase, PsycINFO and PubMed were searched for studies evaluating AD biomarkers with affective symptoms in mild cognitive impairment and AD dementia. Studies were classified according to AT(N) research criteria. Result: Forty-five abstracts fulfilled eligibility criteria, including in total 8,293 patients (41 cross-sectional studies and 7 longitudinal studies). Depression and night-time behaviour disturbances were not related to AT(N) markers. Apathy was associated with A markers (PET, not CSF). Mixed findings were reported for the association between apathy and T(N) markers; anxiety and AT(N) markers; and between agitation and irritability and A markers. Agitation and irritability were not associated with T(N) markers. Discussion: Whereas some AD biomarkers showed to be associated with affective symptoms in AD, most evidence was inconsistent. This is likely due to differences in study design or heterogeneity in affective symptoms. Directions for future research are given.
引用
收藏
页码：346 / 359
页数：14
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