Captopril and its synthesis from chiral intermediates

被引：9

作者：

Chirumamilla, RR ^{[1
]}

Marchant, R ^{[1
]}

Nigam, P ^{[1
]}

机构：

[1] Univ Ulster, Biotechnol Res Grp, Coleraine BT52 1SA, Londonderry, North Ireland

来源：

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 2001年 / 76卷 / 02期

关键词：

captopril; racemic resolution; chiral synthesis; renin-angiotensin;

D O I：

10.1002/jctb.337.abs

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Captopril is an antihypertensive agent that inhibits the angiotensin-converting enzyme of the renin-angiotensin system. Chiral intermediates are used in the synthesis of the drug. These intermediates are obtained by resolution of racemic compounds or by chemical, biocatalytic methods and or by asymmetric synthesis by biocatalytic process. This article reviews the various chemical and biochemical processes involved in the synthesis of the chiral drug, including the pharmacological action of captopril. (C) 2001 Society of Chemical Industry.

引用

页码：123 / 127

页数：5

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