Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity

被引：21

作者：

Anwar, Muhammad ^{[1
]}

Cowley, Andrew R. ^{[1
]}

Moloney, Mark G. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 13-14期

关键词：

DIVERSITY-ORIENTED SYNTHESIS; NATURAL-PRODUCTS; DRUG DISCOVERY; TETRAMIC ACIDS; SERINE; 16-METHYLOXAZOLOMYCIN; INHIBITORS; ALKYLATION; REACTIVITY; MOLECULES;

D O I：

10.1016/j.tetasy.2010.04.064

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1758 / 1770

页数：13

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