Higher frequency of regulatory T suppressive activity cells in the elderly and increased in neurodegeneration

被引：194
作者：
Rosenkranz, Daniela
Weyer, Sascha
Tolosa, Eva
Gaenslen, Alexandra
Berg, Daniela
Leyhe, Thomas
Gasser, Thomas
Stoltze, Lars
机构：
[1] Hertic Inst Clin Brain Res, Dept Gen Neurol, D-72076 Tubingen, Germany
[2] Univ Hosp, Dept Gen Psychiat & Psychotherapy, Tubingen, Germany
[3] Dept Neurodegenerat Disorders, Tubingen, Germany
[4] Dept Cellular Neurol, Tubingen, Germany
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 188卷 / 1-2期
关键词：
immune regulation; Alzheimer's disease; Parkinson disease; ageing; inflammation;
D O I：
10.1016/j.jneuroim.2007.05.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The involvement of regulatory T cells (Treg) in autoinumme-disease development has been demonstrated. However, their alteration during ageing and age-related diseases has not been thoroughly investigated yet. Alzheimer (AD) and Parkinson disease (PD), are related to proteinmisfolding and are accompanied by neuroinflarnmation. Since, it has been hypothesized that the neuroinflainmation attempts to prevent disease development, we speculated that changes in Treg might affect any relevant irru-nune mechanism. The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4(+)Foxp3(+)) increases with age and is accompanied by intensified suppressive activity for Treg in patients. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：117 / 127
页数：11
相关论文
共 54 条
[21]   Autoantibodies to amyloid-β and Alzheimer's disease [J].
Hyman, BT ;
Smith, C ;
Buldyrev, I ;
Whelan, C ;
Brown, H ;
Tang, MX ;
Mayeux, R .
ANNALS OF NEUROLOGY, 2001, 49 (06) :808-810
[22]   PRESENCE OF T-CYTOTOXIC SUPPRESSOR AND LEUKOCYTE COMMON ANTIGEN POSITIVE CELLS IN ALZHEIMERS-DISEASE BRAIN-TISSUE [J].
ITAGAKI, S ;
MCGEER, PL ;
AKIYAMA, H .
NEUROSCIENCE LETTERS, 1988, 91 (03) :259-264
[23]   Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation? [J].
Kerschensteiner, M ;
Gallmeier, E ;
Behrens, L ;
Leal, VV ;
Misgeld, T ;
Klinkert, WEF ;
Kolbeck, R ;
Hoppe, E ;
Oropeza-Wekerle, RL ;
Bartke, I ;
Stadelmann, C ;
Lassmann, H ;
Wekerle, H ;
Hohlfeld, R .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) :865-870
[24]   Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity:: Implications for neurodegeneration [J].
Kipnis, J ;
Cardon, M ;
Avidan, H ;
Lewitus, GM ;
Mordechay, S ;
Rolls, A ;
Shani, Y ;
Schwartz, M .
JOURNAL OF NEUROSCIENCE, 2004, 24 (27) :6133-6143
[25]   Neuroprotective autoimmunity:: Naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system [J].
Kipnis, J ;
Mizrahi, T ;
Hauben, E ;
Shaked, I ;
Shevach, E ;
Schwartz, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15620-15625
[26]   Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II [J].
Kriegel, MA ;
Lohmann, T ;
Gabler, C ;
Blank, N ;
Kalden, JR ;
Lorenz, HM .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (09) :1285-1291
[27]   Inflammatory reaction following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication in mouse [J].
Kurkowska-Jastrzebska, I ;
Wronska, A ;
Kohutnicka, M ;
Czlonkowski, A ;
Czlonkowska, A .
EXPERIMENTAL NEUROLOGY, 1999, 156 (01) :50-61
[28]   Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE [J].
Liu, Yawei ;
Teige, Ingrid ;
Birnir, Bryndis ;
Issazadeh-Navikas, Shohreh .
NATURE MEDICINE, 2006, 12 (05) :518-525
[29]   Effects of α-synuclein immunization in a mouse model of Parkinson's disease [J].
Masliah, E ;
Rockenstein, E ;
Adame, A ;
Alford, M ;
Crews, L ;
Hashimoto, M ;
Seubert, P ;
Lee, M ;
Goldstein, J ;
Chilcote, T ;
Games, D ;
Schenk, D .
NEURON, 2005, 46 (06) :857-868
[30]   ANATOMY AND PATHOLOGY OF THE BASAL GANGLIA [J].
MCGEER, PL ;
MCGEER, EG ;
ITAGAKI, S ;
MIZUKAWA, K .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1987, 14 (03) :363-372
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