Higher frequency of regulatory T suppressive activity cells in the elderly and increased in neurodegeneration

被引：190
|
作者：
Rosenkranz, Daniela
Weyer, Sascha
Tolosa, Eva
Gaenslen, Alexandra
Berg, Daniela
Leyhe, Thomas
Gasser, Thomas
Stoltze, Lars
机构：
[1] Hertic Inst Clin Brain Res, Dept Gen Neurol, D-72076 Tubingen, Germany
[2] Univ Hosp, Dept Gen Psychiat & Psychotherapy, Tubingen, Germany
[3] Dept Neurodegenerat Disorders, Tubingen, Germany
[4] Dept Cellular Neurol, Tubingen, Germany
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 188卷 / 1-2期
关键词：
immune regulation; Alzheimer's disease; Parkinson disease; ageing; inflammation;
D O I：
10.1016/j.jneuroim.2007.05.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The involvement of regulatory T cells (Treg) in autoinumme-disease development has been demonstrated. However, their alteration during ageing and age-related diseases has not been thoroughly investigated yet. Alzheimer (AD) and Parkinson disease (PD), are related to proteinmisfolding and are accompanied by neuroinflarnmation. Since, it has been hypothesized that the neuroinflainmation attempts to prevent disease development, we speculated that changes in Treg might affect any relevant irru-nune mechanism. The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4(+)Foxp3(+)) increases with age and is accompanied by intensified suppressive activity for Treg in patients. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：117 / 127
页数：11
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