A Glutamate Pathway to Faster-Acting Antidepressants?

被引：33

作者：

Cryan, John F. ^{[1
]}

O'Leary, Olivia F. ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Sch Pharm, Dept Pharmacol & Therapeut, Alimentary Pharmabiot Ctr, Cork, Ireland

来源：

SCIENCE | 2010年 / 329卷 / 5994期

关键词：

D-ASPARTATE ANTAGONIST; DEPRESSION; RECEPTORS; RAPAMYCIN; KETAMINE; TRIAL;

D O I：

10.1126/science.1194313

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Activation of mTOR, a ubiquitous protein, in the prefrontal cortex could be a key goal of new drugs.

引用

页码：913 / 914

页数：2

共 20 条

[11] mTOR signaling: At the crossroads of plasticity, memory and disease [J].

Hoeffer, Charles A. ;

Klann, Eric .

TRENDS IN NEUROSCIENCES, 2010, 33 (02) :67-75

[12] mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists [J].

Li, Nanxin ;

Lee, Boyoung ;

Liu, Rong-Jian ;

Banasr, Mounira ;

Dwyer, Jason M. ;

Iwata, Masaaki ;

Li, Xiao-Yuan ;

Aghajanian, George ;

Duman, Ronald S. .

SCIENCE, 2010, 329 (5994) :959-964

[13] Cellular mechanisms underlying the antidepressant effects of ketamine:: Role of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors [J].

Maeng, Sungho ;

Zarate, Carlos A., Jr. ;

Du, Jing ;

Schloesser, Robert J. ;

McCammon, Joseph ;

Chen, Guang ;

Manji, Husseini K. .

BIOLOGICAL PSYCHIATRY, 2008, 63 (04) :349-352

[14] Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design [J].

Mazella, Jean ;

Petrault, Olivier ;

Lucas, Guillaume ;

Deval, Emmanuel ;

Beraud-Dufour, Sophie ;

Gandin, Carine ;

El-Yacoubi, Malika ;

Widmann, Catherine ;

Guyon, Alice ;

Chevet, Eric ;

Taouji, Said ;

Conductier, Gregory ;

Corinus, Alain ;

Coppola, Thierry ;

Gobbi, Gabriella ;

Nahon, Jean-Louis ;

Heurteaux, Catherine ;

Borsotto, Marc .

PLOS BIOLOGY, 2010, 8 (04)

[15] Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: Role of BDNF signalling [J].

O'Leary, Olivia F. ;

Wu, Xuefei ;

Castren, Eero .

PSYCHONEUROENDOCRINOLOGY, 2009, 34 (03) :367-381

[16] Adult hippocampal neurogenesis in depression [J].

Sahay, Amar ;

Hen, Rene .

NATURE NEUROSCIENCE, 2007, 10 (09) :1110-1115

[17] Targeting mTOR globally in cancer Thinking beyond rapamycin [J].

Shor, Boris ;

Gibbons, James J. ;

Abraham, Robert T. ;

Yu, Ker .

CELL CYCLE, 2009, 8 (23) :3831-3837

[18] Glutamate-based antidepressants: 20 years on [J].

Skolnick, Phil ;

Popik, Piotr ;

Trullas, Ramon .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2009, 30 (11) :563-569

[19]

Slattery DA, J PSYCHOPHARMACOL

[20] A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression [J].

Zarate, Carlos A., Jr. ;

Singh, Jaskaran B. ;

Carlson, Paul J. ;

Brutsche, Nancy E. ;

Ameli, Rezvan ;

Luckenbaugh, David A. ;

Charney, Dennis S. ;

Manji, Husseini K. .

ARCHIVES OF GENERAL PSYCHIATRY, 2006, 63 (08) :856-864

← 1 2 →