Phase separation of cholesterol in dimyristoyl phosphatidylserine cholesterol mixtures

被引：36
|
作者：
Bach, D [1 ]
Borochov, N
Wachtel, E
机构：
[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel
[2] Ctr Technol Educ Holon, Holon, Israel
[3] Weizmann Inst Sci, Chem Serv Unit, IL-76100 Rehovot, Israel
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 1998年 / 92卷 / 01期
关键词：
dimyristoyl phosphatidylserine; cholesterol solubility; differential scanning calorimetry; X-ray diffraction;
D O I：
10.1016/S0009-3084(98)00006-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Miscibility of cholesterol in dimyristoyl phosphatidylserine (DMPS) bilayers was investigated by differential scanning calorimetry and X-ray scattering. The onset of cholesterol phase separation as detected by X-ray diffraction is at the molar ratio DMPS:cholesterol of 2:1 and 1.7:1 in the gel and in the liquid crystalline states of the phospholipid, respectively. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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页码：71 / 77
页数：7
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