Phase separation of cholesterol in dimyristoyl phosphatidylserine cholesterol mixtures

被引：36

作者：

Bach, D ^{[1
]}

Borochov, N

Wachtel, E

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

[2] Ctr Technol Educ Holon, Holon, Israel

[3] Weizmann Inst Sci, Chem Serv Unit, IL-76100 Rehovot, Israel

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1998年 / 92卷 / 01期

关键词：

dimyristoyl phosphatidylserine; cholesterol solubility; differential scanning calorimetry; X-ray diffraction;

D O I：

10.1016/S0009-3084(98)00006-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Miscibility of cholesterol in dimyristoyl phosphatidylserine (DMPS) bilayers was investigated by differential scanning calorimetry and X-ray scattering. The onset of cholesterol phase separation as detected by X-ray diffraction is at the molar ratio DMPS:cholesterol of 2:1 and 1.7:1 in the gel and in the liquid crystalline states of the phospholipid, respectively. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：71 / 77

页数：7

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