Single-Cell Proteomics for Cancer Immunotherapy

被引：27

作者：

Li, Linmei ^{[1
]}

Yan, Shiqiang ^{[1
]}

Lin, Bingcheng ^{[1
]}

Shi, Qihui ^{[2
,3
,4
]}

Lu, Yao ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

[2] Fudan Univ, Zhongshan Hosp, Minhang Branch, Shanghai, Peoples R China

[3] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China

[4] Fudan Univ, Minhang Hosp, Inst Fudan Minhang Acad Hlth Syst, Shanghai, Peoples R China

来源：

CANCER NANOTECHNOLOGY-BOOK | 2018年 / 139卷

关键词：

MULTIPLEXED PROTEIN-ANALYSIS; FLOW-CYTOMETRY; MASS CYTOMETRY; T-CELLS; CYTOKINE SECRETION; RESPONSES; ANTIBODY; REVEALS; HETEROGENEITY; LYMPHOMA;

D O I：

10.1016/bs.acr.2018.04.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer immunotherapy fights against cancer by modulating the immune response and is delivering encouraging results in clinical treatments. However, it is challenging to achieve durable response in all cancer patients during treatment due to the diversity and dynamic nature of immune system as well as inter-and intratumor heterogeneity. A comprehensive assessment of system immunity and tumor microenvironment is crucial for effective and safe cancer therapy, which can potentially be resolved by single-cell proteomic analysis. Single-cell proteomic technologies enable system-wide profiling of protein levels in a number of single cells within the immune system and tumor microenvironment, and thereby provide direct assessment of the functional state of the immune cells and tumor-immune interaction that could be used to evaluate efficacy of immunotherapy and to improve clinical outcome. In this chapter, we summarized current single-cell proteomic technologies and their applications in cancer immunotherapy.

引用

页码：185 / 207

页数：23

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