Dietary Nitrate Intake Is Positively Associated with Muscle Function in Men and Women Independent of Physical Activity Levels

被引：12

作者：

Sim, Marc ^{[1
,2
]}

Blekkenhorst, Lauren C. ^{[1
,2
]}

Bondonno, Nicola P. ^{[1
,3
]}

Radavelli-Bagatini, Simone ^{[1
]}

Peeling, Peter ^{[4
,5
]}

Bondonno, Catherine P. ^{[1
,2
]}

Magliano, Dianna J. ^{[6
,7
]}

Shaw, Jonathan E. ^{[6
,7
]}

Woodman, Richard ^{[8
]}

Murray, Kevin ^{[9
]}

Lewis, Joshua R. ^{[1
,2
,10
]}

Daly, Robin M. ^{[11
]}

Hodgson, Jonathan M. ^{[1
,2
]}

机构：

[1] Edith Cowan Univ, Sch Med & Hlth Sci, Inst Nutr Res, Joondalup, WA, Australia

[2] Univ Western Australia, Royal Perth Hosp Unit, Med Sch, Perth, WA, Australia

[3] Univ Western Australia, Sch Biomed Sci, Perth, WA, Australia

[4] Univ Western Australia, Sch Human Sci Exercise & Sports Sci, Perth, WA, Australia

[5] Western Australian Inst Sport, Mt Claremont, WA, Australia

[6] Baker Heart & Diabet Inst, Melbourne, Vic, Australia

[7] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia

[8] Flinders Univ S Australia, Flinders Ctr Epidemiol & Biostat, Adelaide, SA, Australia

[9] Univ Western Australia, Sch Populat & Global Hlth, Perth, WA, Australia

[10] Univ Sydney, Childrens Hosp Westmead, Ctr Kidney Res, Sch Publ Hlth,Sydney Med Sch, Sydney, NSW, Australia

[11] Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr, Geelong, Vic, Australia

来源：

JOURNAL OF NUTRITION | 2021年 / 151卷 / 05期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

muscle strength; physical function; nutrition; vegetables; healthy aging; DISEASE RISK-FACTORS; GRIP STRENGTH; NITRIC-OXIDE; LIFE-STYLE; EXERCISE; SUPPLEMENTATION; PERFORMANCE; CONSENSUS; OBESITY; HEALTH;

D O I：

10.1093/jn/nxaa415

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Nitrate supplements can improve vascular and muscle function. Whether higher habitual dietary nitrate is associated with better muscle function remains underexplored. Objective: The aim was to examine whether habitual dietary nitrate intake is associated with better muscle function in a prospective cohort of men and women, and whether the relation was dependent on levels of physical activity. Methods: The sample (n = 3759) was drawn from the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab) (56% female; mean +/- SD baseline age: 48.6 +/- 11.1 y). Habitual dietary intake was assessed over 12 y by obtaining an average (of at least 2 time points, e.g., baseline (2000/2001) and 2004/2005 and/or 2011/2012) from a food-frequency questionnaire. Nitrate intake was calculated from a validated nitrate database and other published literature. Muscle function was quantified by knee extension strength (KES) and the 8-ft-timed-up-and-go (8ft-TUG) test performed in 2011/2012. Physical activity was assessed by questionnaire. Generalized linear models and logistic regression were used to analyze the data. Results: Median (IQR) total nitrate intake was 65 (52-83) mg/d, with similar to 81% derived from vegetables. Individuals in the highest tertile of nitrate intake (median intake: 91 mg/d) had 2.6 kg stronger KES (11%) and 0.24 s faster 8ft-TUG (4%) compared with individuals in the lowest tertile of nitrate intake (median intake: 47 mg/d; both P < 0.05). Similarly, individuals in the highest tertile of nitrate intake had lower odds for weak KES (adjusted OR: 0.69; 95% CI: 0.47 0.73) and slow 8ft-TUG (adjusted OR: 0.63; 95% CI: 0.50, 0.78) compared with those in the lowest tertile. Physical activity did not influence the relationship between nitrate intake and muscle function (KES; P-interaction = 0.86; 8ft-TUG; P-interaction = 0.99). Conclusions: Higher habitual dietary nitrate intake, predominantly from vegetables, could be an effective way to promote lower-limb muscle strength and physical function in men and women.

引用

页码：1222 / 1230

页数：9

共 51 条

[21] CHEMICAL GENERATION OF NITRIC-OXIDE IN THE MOUTH FROM THE ENTEROSALIVARY CIRCULATION OF DIETARY NITRATE [J].