The Use of 3,5,4′-Tri-O-acetylresveratrol as a Potential Prodrug for Resveratrol Protects Mice from γ-Irradiation-Induced Death

被引：33

作者：

Koide, Kazunori ^{[1
]}

Osman, Sami ^{[1
,2
]}

Garner, Amanda L. ^{[1
,2
]}

Song, Fengling ^{[1
,2
]}

Dixon, Tracy ^{[1
,3
]}

Greenberger, Joel S. ^{[1
,3
]}

Epperly, Michael W. ^{[1
,3
]}

机构：

[1] Univ Pittsburgh, Ctr Med Countermeasures Radiat, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Inst Canc, Hillman Canc Ctr, Dept Radiat Oncol, Pittsburgh, PA 15213 USA

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2011年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Antioxidants; resveratrol; 3,5,4 '-tri-O-acetylresveratrol; radioprotection; Cremophor EL; BONE-MARROW-CELLS; SUPEROXIDE-DISMUTASE; MOUSE; BIOAVAILABILITY; MODULATION; CHEMISTRY; PRODUCTS; RADICALS; SURVIVAL; DAMAGES;

D O I：

10.1021/ml100159p

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Currently, no drugs are available to protect humans from gamma-irradiation-induced death. Because reactive oxygen species are produced upon exposure to gamma-irradiation and directly responsible for the resulting death, we hypothesized that antioxidants found in foodstuffs may provide a safe and potent means of antioxidant-dependent radioprotection. Here, we describe our studies investigating the radioprotective properties of resveratrol and 3,5,4'-tri-O-acetylresveratrol. Each of these natural antioxidants was found to protect live cells after gamma-irradiation. In mice, the use of 3,5,4'-tri-O-acetylresveratrol with Cremophor EL was particularly effective, indicating that this natural antioxidant may be a leading candidate for radioprotective drug development.

引用

页码：270 / 274

页数：5

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