The Use of 3,5,4′-Tri-O-acetylresveratrol as a Potential Prodrug for Resveratrol Protects Mice from γ-Irradiation-Induced Death

被引：33
作者：
Koide, Kazunori [1 ]
Osman, Sami [1 ,2 ]
Garner, Amanda L. [1 ,2 ]
Song, Fengling [1 ,2 ]
Dixon, Tracy [1 ,3 ]
Greenberger, Joel S. [1 ,3 ]
Epperly, Michael W. [1 ,3 ]
机构：
[1] Univ Pittsburgh, Ctr Med Countermeasures Radiat, Pittsburgh, PA 15260 USA
[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
[3] Univ Pittsburgh, Inst Canc, Hillman Canc Ctr, Dept Radiat Oncol, Pittsburgh, PA 15213 USA
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2011年 / 2卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Antioxidants; resveratrol; 3,5,4 '-tri-O-acetylresveratrol; radioprotection; Cremophor EL; BONE-MARROW-CELLS; SUPEROXIDE-DISMUTASE; MOUSE; BIOAVAILABILITY; MODULATION; CHEMISTRY; PRODUCTS; RADICALS; SURVIVAL; DAMAGES;
D O I：
10.1021/ml100159p
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Currently, no drugs are available to protect humans from gamma-irradiation-induced death. Because reactive oxygen species are produced upon exposure to gamma-irradiation and directly responsible for the resulting death, we hypothesized that antioxidants found in foodstuffs may provide a safe and potent means of antioxidant-dependent radioprotection. Here, we describe our studies investigating the radioprotective properties of resveratrol and 3,5,4'-tri-O-acetylresveratrol. Each of these natural antioxidants was found to protect live cells after gamma-irradiation. In mice, the use of 3,5,4'-tri-O-acetylresveratrol with Cremophor EL was particularly effective, indicating that this natural antioxidant may be a leading candidate for radioprotective drug development.
引用
收藏
页码：270 / 274
页数：5
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