Molecularly imprinted polyurethane grafted calcium alginate hydrogel with specific recognition for proteins

被引：12

作者：

Li, Lingxie ^{[1
]}

Ying, Xiaoguang ^{[1
]}

Liu, Jiangquan ^{[1
]}

Li, Xiao ^{[1
]}

Zhang, Weiying ^{[1
]}

机构：

[1] Fuzhou Univ, Coll Chem Engn, Inst Polymer Sci & Engn, Fuzhou 350108, Peoples R China

来源：

MATERIALS LETTERS | 2015年 / 143卷

基金：

中国博士后科学基金;

关键词：

Shape memory materials; Polymers; Protein imprinting; Polyurethane; Alginate; POLYMER MICROSPHERES; CHITOSAN;

D O I：

10.1016/j.matlet.2014.12.108

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Polyurethane grafted calcium alginate hydrogel microspheres intended for bovine serum albumin imprinting were prepared and characterized. The grafting modification was performed prior to the assembling of protein template with hydrogel, which was advantageous to maintain protein conformation and construct more accessible imprinted sites. It was found that the imprinted hydrogel had higher affinity to template molecules after modification. Investigations of grafting ratio influence on specific rebinding and competitive properties indicated that grafted side chains were beneficial to the selective recognition of protein. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：248 / 251

页数：4

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