Genome mining and biosynthesis of fumitremorgin-type alkaloids in ascomycetes

被引：42
作者：
Li, Shu-Ming [1 ]
机构：
[1] Univ Marburg, Inst Pharmazeut Biol & Biotechnol, D-35037 Marburg, Germany
来源：
JOURNAL OF ANTIBIOTICS | 2011年 / 64卷 / 01期
关键词：
biosynthesis; fumitremorgin-type alkaloids; genome mining; MAMMALIAN-CELL CYCLE; CANCER RESISTANCE PROTEIN; ASPERGILLUS-FUMIGATUS FRES; MARINE-DERIVED FUNGUS; PENICILLIUM-VERRUCULOSUM; TREMORGENIC METABOLITE; STEREOCHEMICAL COURSE; SPIROTRYPROSTATIN-B; TRYPROSTATIN-B; RING FORMATION;
D O I：
10.1038/ja.2010.128
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This review summarizes the recent progress on the biosynthesis of fumitremorgin-type alkaloids; that is, the identification of the biosynthetic gene clusters from genome sequences by genome mining and proof of gene function by molecular biological and biochemical investigations. The Journal of Antibiotics (2011) 64, 45-49; doi:10.1038/ja.2010.128; published online 10 November 2010
引用
收藏
页码：45 / 49
页数：5
相关论文
共 38 条
  • [1] Allen JD, 2002, MOL CANCER THER, V1, P417
  • [2] TREMORGENIC TOXIN FROM PENICILLIUM-VERRUCULOSUM
    COLE, RJ
    DAVIS, ND
    BLANKENSHIP, BR
    DIENER, UL
    MOORE, JH
    KIRKSEY, JW
    [J]. APPLIED MICROBIOLOGY, 1972, 24 (02) : 248 - +
  • [3] Spirotryprostatin B, a novel mammalian cell cycle inhibitor produced by Aspergillus fumigatus
    Cui, CB
    Kakeya, H
    Osada, H
    [J]. JOURNAL OF ANTIBIOTICS, 1996, 49 (08) : 832 - 835
  • [4] Novel mammalian cell cycle inhibitors, cyclotryprostatins A-D, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase
    Cui, CB
    Kakeya, H
    Osada, H
    [J]. TETRAHEDRON, 1997, 53 (01) : 59 - 72
  • [5] Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase
    Cui, CB
    Kakeya, H
    Osada, H
    [J]. TETRAHEDRON, 1996, 52 (39) : 12651 - 12666
  • [6] Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus .2. Physico-chemical properties and structures
    Cui, CB
    Kakeya, H
    Osada, H
    [J]. JOURNAL OF ANTIBIOTICS, 1996, 49 (06) : 534 - 540
  • [7] Genome-Based Characterization of Two Prenylation Steps in the Assembly of the Stephacidin and Notoamide Anticancer Agents in a Marine-Derived Aspergillus sp.
    Ding, Yousong
    de Wet, Jeffrey R.
    Cavalcoli, James
    Li, Shengying
    Greshock, Thomas J.
    Miller, Kenneth A.
    Finefield, Jennifer M.
    Sunderhaus, James D.
    McAfoos, Timothy J.
    Tsukamoto, Sachiko
    Williams, Robert M.
    Sherman, David H.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (36) : 12733 - 12740
  • [8] PRODUCTION OF TREMORGENIC MYCOTOXINS VERRUCULOGEN AND FUMITREMORGIN-B BY PENICILLIUM-PISCARIUM WESTLING
    GALLAGHER, RT
    LATCH, GCM
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1977, 33 (03) : 730 - 731
  • [9] Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus
    Grundmann, A
    Li, SM
    [J]. MICROBIOLOGY-SGM, 2005, 151 : 2199 - 2207
  • [10] GRUNDMANN A, 2008, THESIS H HEINE U DUS
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