Genome mining and biosynthesis of fumitremorgin-type alkaloids in ascomycetes

被引：42

作者：

Li, Shu-Ming ^{[1
]}

机构：

[1] Univ Marburg, Inst Pharmazeut Biol & Biotechnol, D-35037 Marburg, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2011年 / 64卷 / 01期

关键词：

biosynthesis; fumitremorgin-type alkaloids; genome mining; MAMMALIAN-CELL CYCLE; CANCER RESISTANCE PROTEIN; ASPERGILLUS-FUMIGATUS FRES; MARINE-DERIVED FUNGUS; PENICILLIUM-VERRUCULOSUM; TREMORGENIC METABOLITE; STEREOCHEMICAL COURSE; SPIROTRYPROSTATIN-B; TRYPROSTATIN-B; RING FORMATION;

D O I：

10.1038/ja.2010.128

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This review summarizes the recent progress on the biosynthesis of fumitremorgin-type alkaloids; that is, the identification of the biosynthetic gene clusters from genome sequences by genome mining and proof of gene function by molecular biological and biochemical investigations. The Journal of Antibiotics (2011) 64, 45-49; doi:10.1038/ja.2010.128; published online 10 November 2010

引用

页码：45 / 49

页数：5

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