Molecular Markers of Arterial Hypertension in Patients with Normotony, Pre-Hypertension and Hypertension

被引：6

作者：

Sherstnev, V. V. ^{[1
]}

Gruden', M. A. ^{[1
]}

Elistratova, E. I. ^{[1
]}

Karlina, V. P. ^{[3
]}

Kuznetsova, A. V. ^{[3
]}

Ryzhova, T. V. ^{[4
]}

Ryzhov, V. M. ^{[2
]}

Sen'ko, O. V. ^{[5
]}

机构：

[1] Russian Acad Med Sci, PK Anokhin Res Inst Human Physiol, Moscow, Russia

[2] Fed Med Biol Agcy Russia, Hosp 170, Korolev, Moscow Region, Russia

[3] Russian Acad Sci, NM Emmanuel Inst Biochem Phys, Moscow, Russia

[4] Fed Med Biol Agcy Russia, Inst Adv Training, Moscow, Russia

[5] Russian Acad Sci, AA Dorodnitsyn Comp Ctr, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 158卷 / 05期

关键词：

biomarkers; hypertension; pre-hypertension; normotony; BLOOD-PRESSURE; BIOMARKERS; POPULATION; PROTEIN; RISK;

D O I：

10.1007/s10517-015-2816-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied concentrations of angiotensin II, HLDF24 peptide, endothelin proteins, S100B, and autoantibodies to them and serum levels of blood natriuretic peptide in patients with different categories of "normal" arterial BP and hypertension. The relationship between blood levels of the above factors and normotony, pre-hypertension, and hypertension in the examined groups was analyzed. The results suggest that the studied molecular factors can serve as potential predictors of arterial hypertension and used for personalized hypertension risk assessment.

引用

页码：604 / 606

页数：3

共 13 条

[1] Contribution of 30 Biomarkers to 10-Year Cardiovascular Risk Estimation in 2 Population Cohorts The MONICA, Risk, Genetics, Archiving, and Monograph (MORGAM) Biomarker Project [J].

Blankenberg, Stefan ;

Zeller, Tanja ;

Saarela, Olli ;

Havulinna, Aki S. ;

Kee, Frank ;

Tunstall-Pedoe, Hugh ;

Kuulasmaa, Kari ;

Yarnell, John ;

Schnabel, Renate B. ;

Wild, Philipp S. ;

Muenzel, Thomas ;

Lackner, Karl J. ;

Tiret, Laurence ;

Evans, Alun ;

Salomaa, Veikko .

CIRCULATION, 2010, 121 (22) :2388-U57

[2] High normal blood pressure and prehypertension: The debate continues [J].

Bolli, Peter ;

Hemmelgarn, Brenda ;

Myers, Martin G. ;

McKay, Donald ;

Tremblay, Guy ;

Tobe, Sheldon W. .

CANADIAN JOURNAL OF CARDIOLOGY, 2007, 23 (07) :581-583

[3]

Cohen Jerome D, 2009, Manag Care, V18, P51

[4] Involvement of HLDF Protein and Anti-HLDF Antibodies in the Mechanisms of Blood Pressure Regulation in Healthy Individuals and Patients with Stable Hypertension and Hypertensive Crisis [J].

Elistratova, E. I. ;

Gruden, M. A. ;

Sherstnev, V. V. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2012, 153 (05) :664-666

[5]

Fomin E. I., 2013, SOVR TEKH MED KLIN M, V5, P38

[6]

Fomin E. I., 2007, SERDTSE, V6, P120

[7]

Gilles T., 2013, J CLIN HYPERTENS, V5, P386

[8]

Golukhova U. Z., 2011, KREATIV KARDIOL, P97

[9] Content of S100b Protein, HLDF24 Peptide and Autoantibodies to These Factors as Potential Biomarkers for Arterial Hypertension in Blood Serum of Healthy People [J].

Gruden, M. A. ;

Elistratova, E. I. ;

Kudrina, M. V. ;

Karlina, V. P. ;

Deryabina, I. S. ;

Semenova, I. M. ;

Ryzhov, V. M. ;

Sherstnev, V. V. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2014, 156 (04) :426-429

[10]

Le Y., 2002, J INTER MED, V275, P430

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