A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase

被引：24
作者：
Feng, Zhi-Chao [1 ,2 ]
Riopel, Matthew [1 ,2 ]
Popell, Alex [1 ,2 ]
Wang, Rennian [1 ,2 ,3 ]
机构：
[1] Childrens Hlth Res Inst, Victoria Res Labs, London, ON N6C 2V5, Canada
[2] Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
[3] Univ Western Ontario, Dept Med, London, ON, Canada
来源：
DIABETOLOGIA | 2015年 / 58卷 / 04期
基金：
加拿大健康研究院;
关键词：
Beta cell growth and function; c-Kit; Review; Stemcell factor; HEMATOPOIETIC PROGENITOR CELLS; GROWTH FACTOR-A; TRANSCRIPTION FACTORS; INSULIN-SECRETION; DOWN-REGULATION; EARLY-ONSET; MAST-CELLS; CROSS-TALK; EXPRESSION; DIFFERENTIATION;
D O I：
10.1007/s00125-015-3504-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The interactions between c-Kit and its ligand, stem cell factor (SCF), play an important role in haematopoiesis, pigmentation and gametogenesis. c-Kit is also found in the pancreas, and recent studies have revealed that c-Kit marks a subpopulation of highly proliferative pancreatic endocrine cells that may harbour islet precursors. c-Kit governs and maintains pancreatic endocrine cell maturation and function via multiple signalling pathways. In this review we address the importance of c-Kit signalling within the pancreas, including its profound role in islet morphogenesis, islet vascularisation, and beta cell survival and function. We also discuss the impact of c-Kit signalling in pancreatic disease and the use of c-Kit as a potential target for the development of cell-based and novel drug therapies in the treatment of diabetes.
引用
收藏
页码：654 / 665
页数：12
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