Extent and evolution of gene duplication in DNA viruses

被引：18

作者：

Gao, Yuxia ^{[1
]}

Zhao, Huayao ^{[1
]}

Jin, Yin ^{[1
]}

Xu, Xiaoyu ^{[1
]}

Han, Guan-Zhu ^{[1
]}

机构：

[1] Nanjing Normal Univ, Coll Life Sci, Jiangsu Engn & Technol Res Ctr Microbiol, Jiangsu Key Lab Microbes & Funct Genom, Nanjing 210046, Jiangsu, Peoples R China

来源：

VIRUS RESEARCH | 2017年 / 240卷

关键词：

DNA virus; Gene duplication; Genome evolution; Genome complexity; PRIMATE LENTIVIRUSES; GIANT VIRUSES; ARMS RACES; EUKARYOTES; GENOMES; POXVIRUSES; INSIGHTS; VPX;

D O I：

10.1016/j.virusres.2017.08.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Gene duplication is the main source of genomic novelties and complexities for both eukaryotes and prokaryotes. In contrast, gene duplication appears to be infrequent in the RNA viruses. However, the extent and evolution of gene duplication in DNA viruses remains obscure. Here we perform a genome-wide analysis of gene duplication in the genomes of 250 DNA viruses that represent all known DNA viral genera. While no gene duplication event is identified in single stranded DNA (ssDNA) or reverse transcribing DNA viruses, gene duplication is frequent among double stranded DNA (dsDNA) viruses. For dsDNA viruses, the number of duplicate genes is significantly correlated with the genome complexity. We find that most of duplicate genes experienced purifying selection on average. Our results indicate that gene duplication play an important role in shaping the evolution of dsDNA viruses.

引用

页码：161 / 165

页数：5

共 36 条

[31] The evolution of large DNA viruses: combining genomic information of viruses and their hosts [J].