GDF11 is increased in patients with myelodysplastic syndrome

被引：0

作者：

Han, Yu ^{[1
]}

Zhang, Gaochao ^{[1
]}

Wang, Huaquan ^{[1
]}

Fu, Rong ^{[1
]}

Xing, Limin ^{[1
]}

Li, Lijuan ^{[1
]}

Jiang, Huijuan ^{[1
]}

Zhang, Wei ^{[1
]}

Tao, Jinglian ^{[1
]}

Shao, Zonghong ^{[1
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Dept Hematol, 154 Anshandao, Tianjin 300052, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2016年 / 9卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Myelodysplastic syndrome; growth differentiation factor 11; anemia; LIGAND TRAP; SKELETAL-MUSCLE; YOUNG BLOOD; ERYTHROPOIESIS; AGE; ANEMIA;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To explore the role of growth differentiation factor 11 (GDF11) in patients with myelodysplastic syndrome (MDS) in erythropoietic functions. Methods: The serum GDF11 in MDS patients was measured using an enzyme-linked immunosorbent assay. The percentage of nucleated erythroid cells (CD235a) in bone marrow was detected via flow cytometry. The correlation between these changes and erythropoietic function were evaluated. GDF11 mRNA expression in bone marrow mononuclear (BMMNC) was detected through real time polymerase chain reaction. Results: The concentration of GDF11 in high-risk MDS patients was significantly higher than that in low-risk MDS patients and higher than that in healthy controls. The concentration of GDF11 in low-risk MDS patients was significantly higher than that in healthy controls. In high-risk MDS patients, the expression of GDF11 was negatively correlated with hemoglobin, red blood cells, and hematocrit and positively correlated with reticulocyte, mean corpuscular volume, CD235a(+) cells, and nucleated erythrocytes in bone marrow. In low-risk MDS patients, the expression of GDF11 was positively correlated with CD235a(+) cells in bone marrow. The mRNA expression of GDF11 of BMMNC in the MDS group was higher than that in the control group. Conclusion: GDF11 was increased in patients with MDS and negatively correlated with late erythropoiesis.

引用

页码：6031 / 6038

页数：8

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