Intensive Care Unit-Acquired Weakness

被引:58
作者
Kramer, Christopher L. [1 ]
机构
[1] Univ Chicago, Dept Neurol, 5841 South Maryland Ave,MC 2050, Chicago, IL 60637 USA
关键词
ICU-acquired weakness; Critical illness neuromyopathy; Critical illness myopathy; Critical illness polyneuropathy; Post-ICU syndrome; CRITICAL ILLNESS POLYNEUROMYOPATHY; CRITICALLY-ILL; DIAPHRAGMATIC DYSFUNCTION; RISK-FACTORS; BED REST; MUSCLE; ICU; MYOPATHY; POLYNEUROPATHY; MORTALITY;
D O I
10.1016/j.ncl.2017.06.008
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Intensive care unit-acquired weakness (ICUAW) is a substantial contributor to long-term disability in survivors of critical illness. Critical illness polyneuropathy, critical illness myopathy, and muscle atrophy from disuse contribute in various proportions to ICUAW. ICUAW is a clinical diagnosis supported by electrophysiology and newer diagnostic tests, such as muscle ultrasound. Risk factor reduction, including the aggressive treatment of sepsis and early mobilization, improves outcome. Although some patients with ICUAW experience a full recovery, for others improvement is slow and incomplete and quality of life is adversely affected. This article examines aspects of ICUAW and identifies potential areas of further study.
引用
收藏
页码:723 / +
页数:15
相关论文
共 54 条
[1]   Acquired weakness, handgrip strength, and mortality in critically ill patients [J].
Ali, Naeem A. ;
O'Brien, James M., Jr. ;
Hoffmann, Stephen P. ;
Phillips, Gary ;
Garland, Allan ;
Finley, James C. W. ;
Almoosa, Khalid ;
Hejal, Rana ;
Wolf, Karen M. ;
Lemeshow, Stanley ;
Connors, Alfred F., Jr. ;
Marsh, Clay B. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 178 (03) :261-268
[2]   Critical illness myopathy: Further evidence from muscle-fiber excitability studies of an acquired channelopathy [J].
Allen, David C. ;
Arunachalam, Ramamurthy ;
Mills, Kerry R. .
MUSCLE & NERVE, 2008, 37 (01) :14-22
[3]   Long-Term Association Between Frailty and Health-Related Quality of Life Among Survivors of Critical Illness: A Prospective Multicenter Cohort Study [J].
Bagshaw, Sean M. ;
Stelfox, H. Thomas ;
Johnson, Jeffrey A. ;
McDermid, Robert C. ;
Rolfson, Darryl B. ;
Tsuyuki, Ross T. ;
Ibrahim, Quazi ;
Majumdar, Sumit R. .
CRITICAL CARE MEDICINE, 2015, 43 (05) :973-982
[4]   The feasibility of measuring frailty to predict disability and mortality in older medical intensive care unit survivors [J].
Baldwin, Matthew R. ;
Reid, M. Cary ;
Westlake, Amanda A. ;
Rowe, John W. ;
Granieri, Evelyn C. ;
Wunsch, Hannah ;
Thuy-Tien Dam ;
Rabinowitz, Daniel ;
Goldstein, Nathan E. ;
Maurer, Mathew S. ;
Lederer, David J. .
JOURNAL OF CRITICAL CARE, 2014, 29 (03) :401-408
[5]   Intensive Care Unit-acquired Weakness Clinical Phenotypes and Molecular Mechanisms [J].
Batt, Jane ;
dos Santos, Claudia C. ;
Cameron, Jill I. ;
Herridge, Margaret S. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187 (03) :238-246
[6]   Molecular mechanisms of intensive care unit-acquired weakness [J].
Bloch, S. ;
Polkey, M. I. ;
Griffiths, M. ;
Kemp, P. .
EUROPEAN RESPIRATORY JOURNAL, 2012, 39 (04) :1000-1011
[7]   Neuromuscular manifestations of critical illness [J].
Bolton, CF .
MUSCLE & NERVE, 2005, 32 (02) :140-163
[8]   POLYNEUROPATHY IN CRITICALLY ILL PATIENTS [J].
BOLTON, CF ;
GILBERT, JJ ;
HAHN, AF ;
SIBBALD, WJ .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1984, 47 (11) :1223-1231
[9]   Ultrasound in the Assessment of Respiration [J].
Boon, Andrea J. ;
O'Gorman, Cullen .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2016, 33 (02) :112-119
[10]   Quantitative neuromuscular ultrasound in intensive care unit-acquired weakness: A systematic review [J].
Bunnell, Aaron ;
Ney, John ;
Gellhorn, Alfred ;
Hough, Catherine L. .
MUSCLE & NERVE, 2015, 52 (05) :701-708