Anc80L65 results in more widespread gene transfer in the CNS of non-human primates compared to AAV9

被引：0
|
作者：
Stanek, L. M. [1 ]
Calcedo, R. [1 ]
Mastis, B. [1 ]
Sanders, D. [1 ]
May, R. [1 ]
Lewis, L. [1 ]
Edwards, M. [1 ]
Tipper, C. [1 ]
Craig, S. [1 ]
Grover, D. [1 ]
Wang, H. [1 ]
Te, L. [1 ]
Vandenberghe, L. H. [1 ,2 ,3 ]
Richman, L. K. [1 ]
机构：
[1] Affinia Therapeut, Waltham, MA USA
[2] Mass Eye & Ear, Grousbeck Gene Therapy Ctr, Boston, MA USA
[3] Harvard Med Sch, Boston, MA 02115 USA
来源：
HUMAN GENE THERAPY | 2021年 / 32卷 / 19-20期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
P058
引用
收藏
页码：A46 / A46
页数：1
相关论文
共 50 条
  • [1] CSF Delivery of Anc80L65 in Nonhuman Primates Results in More Widespread Gene Transfer Throughout the Central Nervous System Compared to AAV9
    Stanek, Lisa M.
    Calcedo, Roberto
    Mastis, Bryan
    Sanders, Doug
    May, Robert
    Lewis, Luke
    Edwards, Matt
    Tipper, Christopher
    Craig, Stewart
    Grover, Deepak
    Wang, Hongxing
    Te, Levy
    Vandenberghe, Luk H.
    Richman, Laura K.
    MOLECULAR THERAPY, 2021, 29 (04) : 179 - 179
  • [2] In-depth comparison of Anc80L65 and AAV9 retinal targeting and characterization of cross-reactivity to multiple AAV serotypes in humans
    Schwartz, Maura K.
    Likhite, Shibi
    Vetter, Tatyana A.
    Baird, Megan C.
    Mcgovern, Vicki
    Delgado, Andrea Sierra
    Mendel, Tom
    Burghes, Arthur
    Meyer, Kathrin C.
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2023, 30 : 16 - 29
  • [3] AAV9 biodistribution and expression in the PNS of Non-Human Primates
    Kagiava, A.
    Casy, W.
    Trygg, C.
    Braun, S. E.
    Gray, S. J.
    Kleopa, K. A.
    HUMAN GENE THERAPY, 2022, 33 (23-24) : A37 - A37
  • [4] Biodistribution and Safety Study of AAV9 in Non-Human Primates
    Lostal, William
    Roudaut, Carinne
    Deschamps, Jack-Yves
    Richard, Isabelle
    MOLECULAR THERAPY, 2018, 26 (05) : 190 - 190
  • [5] Improving Neuronal Gene Transfer to the Brain After CSF Administration of AAV9 in Juvenile Non-Human Primates
    Wright, Maggie
    Lin, Amy
    Park, Soyoung
    Poksay, Karen
    Stoica, Lorelei
    Kistner, Alexander
    Poon, Kirsten
    Chowdhury, Khadiza
    Wadsworth, Sam
    Fyffe-Maricich, Sharyl
    MOLECULAR THERAPY, 2022, 30 (04) : 301 - 301
  • [6] Evaluation of a novel AAV capsid with widespread CNS and peripheral biodistribution in non-human primates
    Ramachandran, Shyam
    Hogestyn, Jessica
    Ayloo, Swathi
    Ryu, Jae
    Ardinger, Jeffery
    Ramos, MiAngela
    Blatnik, Lydia
    Nass, Shelley
    Goulet, Martin
    Mueller, Christian
    Gonzalez-Meneses, Antonio
    MOLECULAR GENETICS AND METABOLISM, 2024, 141 (02)
  • [7] Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65
    Hudry, Eloise
    Andres-Mateos, Eva
    Lerner, Eli P.
    Volak, Adrienn
    Cohen, Olivia
    Hyman, Bradley T.
    Maguire, Casey A.
    Vandenberghe, Luk H.
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2018, 10 : 197 - 209
  • [8] Evaluation of a Novel AAV Capsid with Widespread CNS and Peripheral Biodistribution in Non-Human Primates
    Bu, Jie
    Hogestyn, Jessica
    Ayloo, Swathi
    Ryu, Jae
    Chou, Ben
    Ardinger, Jeffery
    Ramos, Miangela
    Miller, Charles
    Blatnik, Lydia
    Luo, Yuxia
    Richards, Amy
    O'Riordan, Catherine
    Goulet, Martin
    Mueller, Christian
    Ramachandran, Shyam
    MOLECULAR THERAPY, 2024, 32 (04) : 273 - 273
  • [9] Biodistribution and safety of a novel AAV9 gene therapy for treatment of temporal lobe epilepsy shown in non-human primates
    Pearson, N.
    Borta, A.
    Giles, A.
    Sims, J.
    Gaub, B.
    Smith, J.
    Danos, O.
    Mercer, A.
    Porter, R.
    HUMAN GENE THERAPY, 2022, 33 (23-24) : A78 - A78
  • [10] Optimization of intrathecal delivery of an infused AAV9 vector for delivery of a gene therapy candidate for adrenomyeloneuropathy in non-human primates
    Vasireddy, V.
    Clark, S. W.
    Anderson, D. W.
    Kozarsky, K.
    HUMAN GENE THERAPY, 2022, 33 (23-24) : A27 - A27
12345