Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes

被引：88

作者：

Allison, Katrina E. ^{[1
]}

Coomber, Brenda L. ^{[2
]}

Bridle, Byram W. ^{[1
]}

机构：

[1] Univ Guelph, Dept Pathobiol, Ontario Vet Coll, Rm 3808,Bldg 89,50 Stone Rd E, Guelph, ON N1G 2W1, Canada

[2] Univ Guelph, Dept Biomed Sci, Ontario Vet Coll, Guelph, ON, Canada

来源：

IMMUNOLOGY | 2017年 / 152卷 / 02期

关键词：

cancer; T cells; tumour immunology; ACTIVATED PROTEIN-KINASE; PROSTATE-CANCER; MITOCHONDRIAL BIOGENESIS; TRYPTOPHAN CATABOLISM; AEROBIC GLYCOLYSIS; EFFECTOR FUNCTION; METFORMIN; MELANOMA; GROWTH; AMPK;

D O I：

10.1111/imm.12777

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Altered metabolism is a hallmark of cancers, including shifting oxidative phosphorylation to glycolysis and up-regulating glutaminolysis to divert carbon sources into biosynthetic pathways that promote proliferation and survival. Therefore, metabolic inhibitors represent promising anti-cancer drugs. However, T cells must rapidly divide and survive in harsh microenvironments to mediate anti-cancer effects. Metabolic profiles of cancer cells and activated T lymphocytes are similar, raising the risk of metabolic inhibitors impairing the immune system. Immune checkpoint blockade provides an example of how metabolism can be differentially impacted to impair cancer cells but support T cells. Implications for research with metabolic inhibitors are discussed.

引用

页码：175 / 184

页数：10

共 100 条

[1] Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells [J].

Amorim, Ricardo ;

Pinheiro, Celine ;

Miranda-Goncalves, Vera ;

Pereira, Helena ;

Moyer, Mary P. ;

Preto, Ana ;

Baltazar, Fatima .

CANCER LETTERS, 2015, 365 (01) :68-78

[2] Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments [J].

Angelin, Alessia ;

Gil-de-Gomez, Luis ;

Dahiya, Satinder ;

Jiao, Jing ;

Guo, Lili ;

Levine, Matthew H. ;

Wang, Zhonglin ;

Quinn, William J., III ;

Kopinski, Piotr K. ;

Wang, Liqing ;

Akimova, Tatiana ;

Liu, Yujie ;

Bhatti, Tricia R. ;

Han, Rongxiang ;

Laskin, Benjamin L. ;

Baur, Joseph A. ;

Blair, Ian A. ;

Wallace, Douglas C. ;

Hancock, Wayne W. ;

Beier, Ulf H. .

CELL METABOLISM, 2017, 25 (06) :1282-+

[3] Immunosuppression via tryptophan catabolism: The role of kynurenine pathway enzymes [J].

Belladonna, Maria Laura ;

Puccetti, Paolo ;

Orabona, Ciriana ;

Fallarino, Francesca ;

Vacca, Carmine ;

Volpi, Claudia ;

Gizzi, Stefania ;

Pallotta, Maria Teresa ;

Fioretti, Maria Cristina ;

Grohmann, Ursula .

TRANSPLANTATION, 2007, 84 (01) :S17-S20

[4] Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells [J].

Ben Sahra, Issam ;

Laurent, Kathiane ;

Giuliano, Sandy ;

Larbret, Frederic ;

Ponzio, Gilles ;

Gounon, Pierre ;

Le Marchand-Brustel, Yannick ;

Giorgetti-Peraldi, Sophie ;

Cormont, Mireille ;

Bertolotto, Corine ;

Deckert, Marcel ;

Auberger, Patrick ;

Tanti, Jean-Francois ;

Bost, Frederic .

CANCER RESEARCH, 2010, 70 (06) :2465-2475

[5] The Warburg effect and drug resistance [J].

Bhattacharya, Bhaskar ;

Omar, Mohd Feroz Mohd ;

Soong, Richie .

BRITISH JOURNAL OF PHARMACOLOGY, 2016, 173 (06) :970-979

[6] Metabolic Reprogramming of Immune Cells in Cancer Progression [J].

Biswas, Subhra K. .

IMMUNITY, 2015, 43 (03) :435-449

[7] The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo [J].

Blagih, Julianna ;

Coulombe, Francois ;

Vincent, Emma E. ;

Dupuy, Fanny ;

Galicia-Vazquez, Gabriela ;

Yurchenko, Ekaterina ;

Raissi, Thomas C. ;

van der Windt, Gerritje J. W. ;

Viollet, Benoit ;

Pearce, Erika L. ;

Pelletier, Jerry ;

Piccirillo, Ciriaco A. ;

Krawczyk, Connie M. ;

Divangahi, Maziar ;

Jones, Russell G. .

IMMUNITY, 2015, 42 (01) :41-54

[8] Energy disruptors: rising stars in anticancer therapy? [J].

Bost, F. ;

Decoux-Poullot, A-G ;

Tanti, J. F. ;

Clavel, S. .

ONCOGENESIS, 2016, 5 :e188-e188

[9] Tumor-induced perturbations of cytokines and immune cell networks [J].

Burkholder, Brett ;

Huang, Ren-Yu ;

Burgess, Rob ;

Luo, Shuhong ;

Jones, Valerie Sloane ;

Zhang, Wenji ;

Lv, Zhi-Qiang ;

Gao, Chang-Yu ;

Wang, Bao-Ling ;

Zhang, Yu-Ming ;

Huang, Ruo-Pan .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2014, 1845 (02) :182-201

[10] Regulation of cancer cell metabolism [J].

Cairns, Rob A. ;

Harris, Isaac S. ;

Mak, Tak W. .

NATURE REVIEWS CANCER, 2011, 11 (02) :85-95

← 1 2 3 4 5 6 7 8 9 10 →