Recent advances in Cu(II)/Cu(I)-MOFs based nano-platforms for developing new nano-medicines

被引：54

作者：

Sun, Yingman ^{[1
]}

Jiang, Xiaodi ^{[1
]}

Liu, Yiwei ^{[1
]}

Liu, Dong ^{[2
]}

Chen, Chen ^{[1
]}

Lu, Chengyu ^{[1
]}

Zhuang, Shuze ^{[3
]}

Kumar, Abhinav ^{[4
]}

Liu, Jianqiang ^{[1
]}

机构：

[1] Guangdong Med Univ, Sch Pharm, Key Lab Res & Dev New Med Mat, Dongguan 523808, Peoples R China

[2] Shenzhen Huachuang Biopharmaceut Technol Co Ltd, Shenzhen 518112, Guangdong, Peoples R China

[3] Dongguan Sixth Peoples Hosp, 216 Dongcheng West Rd, Guancheng Dist 523808, Dongguan, Peoples R China

[4] Univ Lucknow, Dept Chem, Fac Sci, Lucknow 226007, Uttar Pradesh, India

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2021年 / 225卷

关键词：

Metal organic frameworks; Copper; Nano-medicines; Antibacterial; Mechanism; METAL-ORGANIC FRAMEWORK; COORDINATION POLYMER NANOPARTICLES; MECHANOCHEMICAL SYNTHESIS; ANTIBACTERIAL ACTIVITY; MOF NANOSHEETS; DRUG-DELIVERY; EFFICIENT; LIGAND; NANOPLATFORM; TEMPERATURE;

D O I：

10.1016/j.jinorgbio.2021.111599

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With increasing world population, life-span of humans and spread of viruses, myriad of diseases in human beings are becoming more and more common. Because of the interesting chemical and framework versatility and porosity of metal organic frameworks (MOFs) they find application in varied areas viz. catalysis, sensing, metal ion/gas storage, chemical separation, drug delivery, bio-imaging. This subclass of coordination polymers having interesting three-dimensional framework exhibits inordinate potential and hence may find application in treatment and cure of cancer, diabetes Alzheimer's and other diseases. The presented review focuses on the diverse mechanism of action, unique biological activity and advantages of copper-based metal organic framework (MOF) nanomaterials in medicine. Also, different methods used in the treatment of cancer and other diseases have been presented and the applications as well as efficacy of copper MOFs have been reviewed and discussed. Eventually, the current-status and potential of copper based MOFs in the field of anti-inflammatory, anti-bacterial and anti-cancer therapy as well as further investigations going on for this class of MOF-based multifunctional nanostructures in for developing new nano-medicines have been presented.

引用

页数：11

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