Autophagy and immune microenvironment in craniopharyngioma and ameloblastoma

被引：13

作者：

Karpathiou, Georgia ^{[1
]}

Hamlat, Mehdi ^{[1
]}

Dridi, Maroa ^{[1
]}

Forest, Fabien ^{[1
]}

Papoudou-Bai, Alexandra ^{[2
]}

Dumollard, Jean Marc ^{[1
]}

Peoc'h, Michel ^{[1
]}

机构：

[1] Univ Hosp St Etienne, Pathol Dept, F-42055 St Etienne 2, France

[2] Univ Hosp Ioannina, Pathol Dept, Ioannina, Greece

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2021年 / 123卷

关键词：

Odontogenic; LC3B; p62; Lymphocytes; PD-L1; Macrophages; MECA-79; High endothelial venules; PROGNOSTIC-SIGNIFICANCE; P62;

D O I：

10.1016/j.yexmp.2021.104712

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background: Craniopharyngiomas and ameloblastomas show remarkable histologic and molecular similarities. The immune microenvironment of craniopharyngiomas has been recently studied showing interesting findings, while its composition in ameloblastomas is unknown. Similarly, some evidence of autophagic activity, a process of cellular constituents' degradation has been found in ameloblastomas, but no studies exist in craniopharyngiomas. Thus, the aim of the study is to compare factors of the immune microenvironment and the autophagic apparatus between these two tumor types. Methods: 26 craniopharyngiomas and 14 ameloblastomas were immunohistochemically studied for PD-L1, CD8, CD20, S100, CD163, MECA-79, LC3B and p62. Results: Craniopharyngiomas showed higher LC3B tumor cell expression, higher CD8+ T cells and higher CD163+ macrophages in comparison to ameloblastomas. LC3B tumor cell expression was associated with overall survival in craniopharyngioma patients and p62 nuclear expression was associated with overall survival in ameloblastoma patients. Conclusion: This is the first study showing the presence of autophagic markers in craniopharyngiomas and describing the immune microenvironment of ameloblastomas.

引用

页数：8

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