Predictive and Prognostic Factors in HCC Patients Treated with Sorafenib

被引：60

作者：

Brunetti, Oronzo ^{[1
]}

Gnoni, Antonio ^{[2
]}

Licchetta, Antonella ^{[2
]}

Longo, Vito ^{[3
]}

Calabrese, Angela ^{[4
]}

Argentiero, Antonella ^{[1
]}

Delcuratolo, Sabina ^{[5
]}

Solimando, Antonio Giovanni ^{[1
,6
]}

Casadei-Gardini, Andrea ^{[7
,8
]}

Silvestris, Nicola ^{[1
,9
]}

机构：

[1] Ist Tumori Giovanni Paolo II, Med Oncol Unit, IRCCS, Natl Canc Res Ctr, I-70124 Bari, Italy

[2] S Cuore di Gesu Hosp, Med Oncol Unit, I-73014 Gallipoli, Italy

[3] Ist Tumori Giovanni Paolo II, Med Thorac Oncol Unit, IRCCS, I-70124 Bari, Italy

[4] Ist Tumori Giovanni Paolo II, Radiol Unit, IRCCS, Natl Canc Res Ctr, I-70124 Bari, Italy

[5] Ist Tumori Giovanni Paolo II, IRCCS, Natl Canc Res Ctr, Sci Direct, I-70124 Bari, Italy

[6] Univ Bari, Dept Biomed Sci & Human Oncol, Sect Internal Med G Baccelli, Med Sch, I-70124 Bari, Italy

[7] IRCCS, Dept Med Oncol, Ist Sci Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, Italy

[8] Univ Hosp Modena, Dept Oncol & Haematol, I-41125 Modena, Italy

[9] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy

来源：

MEDICINA-LITHUANIA | 2019年 / 55卷 / 10期

关键词：

Sorafenib; hepatocellular carcinoma; prognostic factors; predictive factors; ADVANCED HEPATOCELLULAR-CARCINOMA; ALPHA-FETOPROTEIN; LYMPHOCYTE RATIO; GROWTH-FACTOR; SURVIVAL; THERAPY; MICRORNAS; METFORMIN; EFFICACY; CELLS;

D O I：

10.3390/medicina55100707

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sorafenib is an oral kinase inhibitor that enhances survival in patients affected by advanced hepatocellular carcinoma (HCC). According to the results of two registrative trials, this drug represents a gold quality standard in the first line treatment of advanced HCC. Recently, lenvatinib showed similar results in terms of survival in a non-inferiority randomized trial study considering the same subset of patients. Unlike other targeted therapies, predictive and prognostic markers in HCC patients treated with sorafenib are lacking. Their identification could help clinicians in the daily management of these patients, mostly in light of the new therapeutic options available in the first.

引用

页数：16

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