Alkyne-Modulated Surface-Enhanced Raman Scattering-Palette for Optical Interference-Free and Multiplex Cellular Imaging

被引:108
作者
Chen, Yong [1 ]
Ren, Jia-Qiang [1 ]
Zhang, Xia-Guang [2 ,3 ,4 ]
Wu, De-Yin [2 ,3 ,4 ]
Shen, Ai-Guo [1 ]
Hu, Ji-Ming [1 ]
机构
[1] Wuhan Univ, Coll Chem & Mol Sci, Key Lab Analyt Chem Biol & Med, Minist Educ, Wuhan 430072, Peoples R China
[2] Xiamen Univ, Collaborat Innovat Ctr Chem Energy Mat, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China
[3] Xiamen Univ, Dept Chem, Xiamen 361005, Peoples R China
[4] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China
基金
中国国家自然科学基金;
关键词
VIVO CANCER-DETECTION; MAMMALIAN-CELLS; SERS; SPECTROSCOPY; PROBE; NANOPARTICLES; NANOTAGS; PLANT; TAGS;
D O I
10.1021/acs.analchem.6b01374
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The alkyne tags possess unique interference-free Raman emissions but are still hindered for further application in the field of biochemical labels due to its extremely weak spontaneous Raman scattering. With the aid of computational chemistry, herein, an alkyne-modulated surface-enhanced Raman scattering (SERS) palette is constructed based on rationally designed 4-ethynylbenzenethiol derivatives for spectroscopic signature, Au@Ag core for optical enhancement and an encapsulating polyallylamine shell for protection and conjugation. Even for the pigment rich plant cell (e.g., pollen), the alkyne-coded SERS tag can be highly discerned on two-dimension distribution impervious to strong organic interferences originating from resonance-enhanced Raman scattering or autofluorescence. In addition, the alkynyl-containing Raman reporters contribute especially narrow emission, band shift-tunable (2100-2300 cm(-1)) and tremendously enhanced Raman signals when the alkynyl group locates at para position of mercaptobenzene ring. Depending on only single Raman band, the suggested alkyne-modulated SERS-palette potentially provides a more effective solution for multiplex cellular imaging with vibrant colors, when the hyperspectral and fairly intense optical noises originating from lower wavenumber region (<1800 cm(-1)) are inevitable under complex ambient conditions.
引用
收藏
页码:6115 / 6119
页数:5
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