The interaction between RNA polymerase and the elongation factor NusA

被引：12
|
作者：
Yang, Xiao [1 ]
Lewis, Peter J. [1 ]
机构：
[1] Univ Newcastle, Sch Environm & Life Sci, Callaghan, NSW 2308, Australia
来源：
RNA BIOLOGY | 2010年 / 7卷 / 03期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
bacterial RNAP; NusA; transcription regulation; ESCHERICHIA-COLI; TRANSCRIPTION ELONGATION; CRYSTAL-STRUCTURE; ANGSTROM RESOLUTION; NASCENT RNA; TERMINATION; COMPLEX; BINDING; SIGMA(70); DOMAIN;
D O I：
10.4161/rna.7.3.12021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of RNA is highly regulated at all stages by transcription factors. As an essential transcription elongation factor, NusA has been studied biochemically for more than 30 years. However, until now no structural information has been available on NusA-RNAP complexes and the NusA interaction site on RNAP was a point of speculation. Determination of the structure of RNA polymerase in complex with NusA is helping us understand how NusA regulates transcription. The resulting model of RNA polymerase in complex with NusA has shed light on the transition from the initiation to elongation stages of transcription, and how NusA functions in promoting regulatory pausing and termination.
引用
收藏
页码：272 / 275
页数：4
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