IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury

被引：44

作者：

Gao, Weiwei ^{[1
]}

Li, Fei ^{[1
]}

Zhou, Ziwei ^{[1
]}

Xu, Xin ^{[1
]}

Wu, Yingang ^{[1
]}

Zhou, Shuai ^{[1
]}

Yin, Dongpei ^{[1
]}

Sun, Dongdong ^{[1
]}

Xiong, Jianhua ^{[1
]}

Jiang, Rongcai ^{[1
]}

Zhang, Jianning ^{[1
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Key Lab Postneurotrauma Neurorepair & Regenerat C, Dept Neurosurg,Minist Educ & Tianjin City, Tianjin, Peoples R China

来源：

FRONTIERS IN NEUROLOGY | 2017年 / 8卷

基金：

中国国家自然科学基金;

关键词：

traumatic brain injury; IL-2/anti-IL-2; regulatory T cells; microglia; inflammation; blood-brain barrier; REGULATORY T-CELLS; CONTROLLED CORTICAL IMPACT; INTRACEREBRAL HEMORRHAGE; CEREBRAL-ISCHEMIA; IMMUNE-SYSTEM; SPINAL-CORD; TGF-BETA; MICROGLIA; STROKE; ACTIVATION;

D O I：

10.3389/fneur.2017.00281

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Traumatic brain injury (TBI) induces the excessive inflammation and disruption of blood-brain barrier, both of which are partially mediated by the activation of microglia and release of inflammatory cytokines. Previous reports showed that administration of regulatory T cells (Tregs) could suppress inflammation and promote neurological function recovery, and that the IL-2/anti-IL-2 complex (IL-2C) could increase the number of Tregs. Thus, we hypothesized that IL-2C-mediated expansion of Tregs would be beneficial in mice subjected to TBI. In this study, mice received an intraperitoneal injection of IL-2C for three consecutive days. We observed that IL-2C dose-dependently increased Tregs without affecting the populations of CD4, CD8, or natural killer cells. IL-2C could improve the neurological recovery and reduce brain edema, tissue loss, neutrophils infiltration, and tight junction proteins degradation. Furthermore, this complex could also reduce the expression of CD16/32, IL-1 beta, or TNF-alpha, and elevate the expression of CD206, arginase 1, or TGF-beta. These results suggest that IL-2C could be a potential therapeutic method to alleviate excessive inflammation and maintain blood vessel stability after TBI.

引用

页数：13

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