Syntheses, Crystal Structures and Biological Activity of 2-Oxo-3-phenylpropionic Acid Aroyl Hydrazone Di-2,4-dichlorobenzyltin Complexes

被引：7

作者：

Jiang Wu-Jiu ^{[1
]}

Tan Yu-Xing ^{[1
]}

Yu Jiang-Xi ^{[1
]}

Zhu Xiao-Ming ^{[1
]}

Zhang Fu-Xing ^{[1
]}

Kuang Dai-Zhi ^{[1
]}

机构：

[1] Hengyang Normal Univ, Key Lab Funct Organometall Mat, Coll Chem & Mat Sci, Coll Hunan Prov, Hengyang 421008, Hunan, Peoples R China

来源：

CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2016年 / 32卷 / 08期

关键词：

organotin complex; hydrazone; synthesis; crystal structure; biological activity; DIORGANOTIN IV COMPLEXES; ORGANOTIN COMPOUNDS; ANTITUMOR-ACTIVITY; CANCER-CELLS; SCHIFF-BASE; THERMAL-STABILITY; DNA-BINDING; IN-VITRO; CHEMISTRY;

D O I：

10.11862/CJIC.2016.179

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two substituted benzyltin complexes has been synthesized via the reaction of 2-oxo-3-phenylpropionic acid aroyl hydrazone with di-2,4-dichlorobenzyltin dichloride. The complexes Cl and C2 have been characterized by IR, UV-Vis, H-1 NMR, C-13 NMR Sn-119 NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. In vitro antitumor activities of both complexes were evaluated by 3-(4,5-dimethylthiazoly-2-yl)- 2,5- diphenyltetrazolium bromide (MTT) assay against five human cancer cell lines (Hela, MCF7, HepG2, Colo205, NCI-H460) and two human cell lines (HEK293, HL7702). Two Complexes exhibited strong antitumor activity. Moreover, C2 less toxic than Cl. The interaction between complexes and calf thymus DNA were studied by EB fluorescent probe. The results show that the interaction of Cl with calf thymus DNA were intercalation and electrostatic attraction. However, the C2 were intercalation. CCDC: 1452066, Cl; 1452067, C2.

引用

页码：1383 / 1390

页数：8

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