High prevalence of Hepatitis E virus in French domestic pigs

被引：104

作者：

Rose, Nicolas ^{[1
]}

Lunazzi, Aurelie ^{[2
]}

Dorenlor, Virginie ^{[1
]}

Merbah, Thiziri ^{[2
]}

Eono, Florent ^{[1
]}

Eloit, Marc ^{[3
]}

Madec, Francois ^{[1
]}

Pavio, Nicole ^{[2
]}

机构：

[1] Anses, Lab Ploufragan Plouzane, F-22440 Ploufragan, France

[2] Anses, Lab Sante Anim, ENVA, INRA, F-94706 Maisons Alfort, France

[3] Anses, Ecole Natl Vet Alfort, INRA, ENVA, F-94704 Maisons Alfort, France

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2011年 / 34卷 / 05期

关键词：

Hepatitis E; Pig; Animal reservoir; Zoonosis; Public health; UNITED-STATES; BLOOD-DONORS; ANTIBODIES; SWINE; TRANSMISSION; INFECTION; IDENTIFICATION; DIVERSITY; STRAINS; LIVERS;

D O I：

10.1016/j.cimid.2011.07.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The importance of the domestic pig reservoir for Hepatitis E virus (HEV) was assessed by estimating the seroprevalence and prevalence of HEV contaminated livers in French slaughter-aged pigs. 6565 sera and 3715 livers were randomly sampled from 186 pig farms throughout the country. Taking the sampling design into account, the farm-level seroprevalence was 65% (95% CI 57-74) and 31% (95% CI 24-38) of the slaughter-aged pigs had antibodies against HEV. The individual prevalence of HEV RNA positive livers was 4% (95% CI 2-6) and 24% (95% CI 17-31) of the farms had at least 1 positive liver. Most isolates were of genotype 3f (76.7%) with smaller amounts of 3c (18.6%) and 3e (4.6%). The high prevalence of HEV in pigs and the similarities between HEV subtypes from pigs and humans corroborates the possible zoonotic origin of some HEV autochthonous infections. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：419 / 427

页数：9

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