Mdm2's Dilemma: To Degrade or To Translate p53?

被引：22
作者：
Hamard, Pierre-Jacques [1 ]
Manfredi, James J. [1 ]
机构：
[1] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10029 USA
来源：
CANCER CELL | 2012年 / 21卷 / 01期
关键词：
D O I：
10.1016/j.ccr.2011.12.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Cell, Gajjar et al. provide insight into how Mdm2 can both inhibit and enhance p53 activity. In the basal setting, Mdm2 binds p53 and promotes p53 degradation. Under stress conditions, ATM-dependent phosphorylation of Mdm2 results in its recruitment to p53 mRNA, thereby stimulating p53 translation.
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收藏
页码：3 / 5
页数：3
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[11]   The contribution of the acidic domain of MDM2 to p53 and MDM2 stability [J].
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[13]   MDM2 AND P53 - A QUESTION OF BALANCE [J].
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JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (17) :1265-1266
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[15]   p53 ubiquitination: Mdm2 and beyond [J].
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[16]   The p53 and Mdm2 families in cancer [J].
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[17]   Hdmx stabilizes Mdm2 and p53 [J].
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Little, N ;
Grivell, S ;
Attema, J ;
van der Eb, AJ ;
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