Non-Coding RNAs: Prevention, Diagnosis, and Treatment in Myocardial Ischemia-Reperfusion Injury

被引：58

作者：

Marinescu, Mihnea-Cosmin ^{[1
,2
]}

Lazar, Andrada-Luciana ^{[3
]}

Marta, Monica Mihaela ^{[4
]}

Cozma, Angela ^{[5
]}

Catana, Cristina-Sorina ^{[6
]}

机构：

[1] Cty Clin Emergency Hosp Brasov Romania, Brasov 500326, Romania

[2] Iuliu Hatieganu Univ Med & Pharm, Surg Clin 2, Dept Vasc Surg, Cluj Napoca 400012, Romania

[3] Iuliu Hatieganu Univ Med & Pharm, Dept Dermatol, Cluj Napoca 400012, Romania

[4] Iuliu Hatieganu Univ Med & Pharm, Dept Med Educ, Cluj Napoca 400012, Romania

[5] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med, Cluj Napoca 400012, Romania

[6] Iuliu Hatieganu Univ Med & Pharm, Dept Med Biochem, Cluj Napoca 400012, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 05期

关键词：

microRNA; long non-coding RNA; cardiovascular diseases; ischemia-reperfusion injury; biomarker; acute myocardial infarction; ISCHEMIA/REPERFUSION INJURY; CARDIAC-HYPERTROPHY; DOWN-REGULATION; ANTI-APOPTOSIS; HEART; MICRORNA; INFARCTION; INHIBITION; EXPRESSION; PROTECTS;

D O I：

10.3390/ijms23052728

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent knowledge concerning the role of non-coding RNAs (ncRNAs) in myocardial ischemia/reperfusion (I/R) injury provides new insight into their possible roles as specific biomarkers for early diagnosis, prognosis, and treatment. MicroRNAs (miRNAs) have fewer than 200 nucleotides, while long ncRNAs (lncRNAs) have more than 200 nucleotides. The three types of ncRNAs (miRNAs, lncRNAs, and circRNAs) act as signaling molecules strongly involved in cardiovascular disorders (CVD). I/R injury of the heart is the main CVD correlated with acute myocardial infarction (AMI), cardiac surgery, and transplantation. The expression levels of many ncRNAs and miRNAs are highly modified in the plasma of MI patients, and thus they have the potential to diagnose and treat MI. Cardiomyocyte and endothelial cell death is the major trigger for myocardial ischemia-reperfusion syndrome (MIRS). The cardioprotective effect of inflammasome activation in MIRS and the therapeutics targeting the reparative response could prevent progressive post-infarction heart failure. Moreover, the pharmacological and genetic modulation of these ncRNAs has the therapeutic potential to improve clinical outcomes in AMI patients.

引用

页数：15

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