Microfluidic quadrupole and floating concentration gradient

被引:72
作者
Qasaimeh, Mohammad A. [1 ,2 ]
Gervais, Thomas [3 ]
Juncker, David [1 ,2 ,4 ]
机构
[1] McGill Univ, Dept Biomed Engn, Montreal, PQ H3A 1A4, Canada
[2] McGill Univ, Genome Quebec Innovat Ctr, Montreal, PQ H3A 1A4, Canada
[3] Ecole Polytech Montreal, Dept Engn Phys, Montreal, PQ H3C 3A7, Canada
[4] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 1A4, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
CELL-MIGRATION; CHEMOTAXIS; DIFFUSION; SUBSTRATE; TRANSPORT; BIOFILMS;
D O I
10.1038/ncomms1471
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The concept of fluidic multipoles, in analogy to electrostatics, has long been known as a particular class of solutions of the Navier-Stokes equation in potential flows; however, experimental observations of fluidic multipoles and of their characteristics have not been reported yet. Here we present a two-dimensional microfluidic quadrupole and a theoretical analysis consistent with the experimental observations. The microfluidic quadrupole was formed by simultaneously injecting and aspirating fluids from two pairs of opposing apertures in a narrow gap formed between a microfluidic probe and a substrate. A stagnation point was formed at the centre of the microfluidic quadrupole, and its position could be rapidly adjusted hydrodynamically. Following the injection of a solute through one of the poles, a stationary, tunable, and movable-that is, 'floating'-concentration gradient was formed at the stagnation point. Our results lay the foundation for future combined experimental and theoretical exploration of microfluidic planar multipoles including convective-diffusive phenomena.
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页数:8
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