One-year outcomes of patients undergoing complex percutaneous coronary intervention with three contemporary drug-eluting stents

被引：7

作者：

Azzalini, Lorenzo ^{[1
]}

Baber, Usman ^{[1
]}

Johal, Gurpreet S. ^{[1
]}

Farhan, Serdar ^{[1
]}

Barman, Nitin ^{[1
]}

Kapur, Vishal ^{[1
]}

Hasan, Choudhury ^{[1
]}

Vijay, Pooja ^{[1
]}

Jhaveri, Vaishvi ^{[1
]}

Mehran, Roxana ^{[1
]}

Kini, Annapoorna S. ^{[1
]}

Sharma, Samin K. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, One Gustave L Levy Pl,Box 1030, New York, NY 10029 USA

来源：

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS | 2021年 / 97卷 / 07期

关键词：

atherectomy; bioresorbable polymer; calcified lesions; complex PCI; drug-eluting stent; durable polymer; EFFICACY; SAFETY;

D O I：

10.1002/ccd.28996

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives We aimed to evaluate the 1-year outcomes of three everolimus-eluting stents (EES) for complex percutaneous coronary intervention (PCI). Background It is controversial whether contemporary bioresorbable-polymer drug-eluting stents (BP-DES) are associated with better outcomes compared with durable-polymer DES (DP-DES). Methods Patients undergoing PCI with cobalt-chromium (CoCr)-DP-EES (Xience), platinum-chromium (PtCr)-DP-EES (Promus), or PtCr-BP-EES (Synergy) at one high-volume institution between 2015 and 2017 were included. The primary endpoint was 1-year major adverse cardiac events (MACE), a composite of death, myocardial infarction, and target-vessel revascularization. Associations were also examined in patients undergoing complex PCI. Multivariable analysis was conducted to adjust for baseline differences across groups. Results We included n = 5,446 patients (CoCr-DP-EES, n = 3,177; PtCr-DP-EES, n = 1,555; PtCr-BP-EES, n = 714). Patients treated with PtCr-BP-EES had higher comorbidity burden and procedural complexity. At 1 year, MACE rates were 8.9% for CoCr-DP-EES versus 8.9% for PtCr-DP-EES versus 8.6% for PtCr-BP-EES (p = .97). The incidence of definite/probable stent thrombosis (ST) was also similar (0.6 vs. 0.4 vs. 0.3%, p = .69). Complex PCI was performed in n = 2,894/5,446 (53.1%). At 1 year, MACE rates were 11.5 versus 10.7 versus 10.3%, respectively (p = .83). The incidence of definite/probable ST was also similar (0.9 vs. 0.3 vs. 0.3%, p = .22). On multivariable analysis, stent type was not an independent predictor of MACE either in the overall or in the complex PCI population. Conclusions We observed comparable 1-year rates of MACE and definite/probable ST in patients undergoing PCI with CoCr-DP-EES, PtCr-DP-EES, and PtCr-BP-EES. Results were unchanged among patients undergoing complex PCI. Future multicenter randomized studies should confirm and extend our findings.

引用

页码：1341 / 1351

页数：11

共 20 条

[1] Long-Term Outcomes of Chronic Total Occlusion Recanalization Versus Percutaneous Coronary Intervention for Complex Non-Occlusive Coronary Artery Disease [J].

Azzalini, Lorenzo ;

Carlino, Mauro ;

Bellini, Barbara ;

Marini, Claudia ;

Pazzanese, Vittorio ;

Toscano, Evelina ;

Gramegna, Mario ;

Moscardelli, Silvia ;

Bognoni, Ludovica ;

Montorfano, Matteo .

AMERICAN JOURNAL OF CARDIOLOGY, 2020, 125 (02) :182-188

[2] Risk of contrast-induced nephropathy in patients undergoing complex percutaneous coronary intervention [J].

Azzalini, Lorenzo ;

Poletti, Enrico ;

Lombardo, Francesca ;

Laricchia, Alessandra ;

Beneduce, Alessandro ;

Moscardelli, Silvia ;

Bellini, Barbara ;

Maccagni, Davide ;

Cappelletti, Alberto ;

Ancona, Marco B. ;

Carlino, Mauro ;

Chieffo, Alaide ;

Colombo, Antonio ;

Montorfano, Matteo .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2019, 290 :59-63

[3] Bare metal stents, durable polymer drug eluting stents, and biodegradable polymer drug eluting stents for coronary artery disease: mixed treatment comparison meta-analysis [J].

Bangalore, Sripal ;

Toklu, Bora ;

Amoroso, Nicholas ;

Fusaro, Mario ;

Kumar, Sunil ;

Hannan, Edward L. ;

Faxon, David P. ;

Feit, Frederick .

BMJ-BRITISH MEDICAL JOURNAL, 2013, 347

[4] Coronary balloon angioplasty, stents, and scaffolds [J].

Byrne, Robert A. ;

Stone, Gregg W. ;

Ormiston, John ;

Kastrati, Adnan .

LANCET, 2017, 390 (10096) :781-792

[5] Meta-Analysis of Randomized Clinical Trials Comparing Biodegradable Polymer Drug-Eluting Stent to Second-Generation Durable Polymer Drug- Eluting Stents [J].

El-Hayek, Georges ;

Bangalore, Sripal ;

Dominguez, Abel Casso ;

Devireddy, Chandan ;

Jaber, Wissam ;

Kumar, Gautam ;

Mavromatis, Kreton ;

Tamis-Holland, Jacqueline ;

Samady, Habib .

JACC-CARDIOVASCULAR INTERVENTIONS, 2017, 10 (05) :462-473

[6] Standardized End Point Definitions for Coronary Intervention Trials [J].

Garcia-Garcia, Hector M. ;

McFadden, Eugene P. ;

Farb, Andrew ;

Mehran, Roxana ;

Stone, Gregg W. ;

Spertus, John ;

Onuma, Yoshinobu ;

Morel, Marie-angele ;

van Es, Gerrit-Anne ;

Zuckerman, Bram ;

Fearon, William F. ;

Taggart, David ;

Kappetein, Arie-Pieter ;

Krucoff, Mitchell W. ;

Vranckx, Pascal ;

Windecker, Stephan ;

Cutlip, Donald ;

Serruys, Patrick W. .

EUROPEAN HEART JOURNAL, 2018, 39 (23) :2192-2207

[7] Efficacy and Safety of Dual Antiplatelet Therapy After Complex PCI [J].

Giustino, Gennaro ;

Chieffo, Alaide ;

Palmerini, Tullio ;

Valgimigli, Marco ;

Feres, Fausto ;

Abizaid, Alexandre ;

Costa, Ricardo A. ;

Hong, Myeong-Ki ;

Kim, Byeong-Keuk ;

Jang, Yangsoo ;

Kim, Hyo-Soo ;

Park, Kyung Woo ;

Gilard, Martine ;

Morice, Marie-Claude ;

Sawaya, Fadi ;

Sardella, Gennaro ;

Genereux, Philippe ;

Redfors, Bjorn ;

Leon, Martin B. ;

Bhatt, Deepak L. ;

Stone, Gregg W. ;

Colombo, Antonio .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (17) :1851-1864

[8] Ultrathin, bioresorbable polymer sirolimus-eluting stents versus thin, durable polymer everolimus-eluting stents in patients undergoing coronary revascularisation (BIOFLOW V): a randomised trial [J].

Kandzari, David E. ;

Mauri, Laura ;

Koolen, Jacques J. ;

Massaro, Joseph M. ;

Doros, Gheorghe ;

Garcia-Garcia, Hector M. ;

Bennett, Johan ;

Roguin, Ariel ;

Gharib, Elie G. ;

Cutlip, Donald E. ;

Waksman, Ron .

LANCET, 2017, 390 (10105) :1843-1852

[9] Long-Term Safety and Efficacy of Platinum Chromium Everolimus-Eluting Stents in Coronary Artery Disease 5-Year Results From the PLATINUM Trial [J].

Kelly, Christopher R. ;

Teirstein, Paul S. ;

Meredith, Ian T. ;

Farah, Bruno ;

Dubois, Christophe L. ;

Feldman, Robert L. ;

Dens, Joseph ;

Hagiwara, Nobuhisa ;

Rabinowitz, Abram ;

Carrie, Didier ;

Pompili, Vincent ;

Bouchard, Alain ;

Saito, Shigeru ;

Allocco, Dominic J. ;

Dawkins, Keith D. ;

Stone, Gregg W. .

JACC-CARDIOVASCULAR INTERVENTIONS, 2017, 10 (23) :2392-2400

[10] Clinical Outcomes Following Implantation of Thin-Strut, Bioabsorbable Polymer-Coated, Everolimus-Eluting SYNERGY Stents Final 5-Year Results of the EVOLVE II Randomized Trial [J].

Kereiakes, Dean J. ;

Windecker, Stephan ;

Jobe, R. Lee ;

Mehta, Shamir R. ;

Sarembock, Ian J. ;

Feldman, Robert L. ;

Stein, Bernardo ;

Dubois, Christophe ;

Grady, Timothy ;

Saito, Shigeru ;

Kimura, Takeshi ;

Underwood, Paul ;

Allocco, Dominic J. ;

Meredith, Ian T. .

CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2019, 12 (09)

← 1 2 →