The legacy of "just the facts"

This commentary to the capstone paper by Keshavan and colleagues reflects on the history of this project and the challenging nature of curating and establishing facts. While a number of approaches exist, none of them in-and-of-themselves are without drawbacks. A combination of techniques may provide the most satisfying results. We emphasize the importance of determining what facts are specific to the disorder - a particularly challenging endeavor - and the usefulness of various ways of quantifying these facts. (C) 2011 Elsevier B.V. All rights reserved.