Cationic Ruthenium(II) Catalysts for Oxidative C-H/N-H Bond Functionalizations of Anilines with Removable Directing Group: Synthesis of Indoles in Water

被引：324

作者：

Ackermann, Lutz ^{[1
]}

Lygin, Alexander V. ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 03期

关键词：

REACTION SEQUENCE; DIRECT ARYLATIONS; PALLADIUM; ACTIVATION; ALKYNES; ANNULATION; CONSTRUCTION; COMPLEXES; ARENE;

D O I：

10.1021/ol203309y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cationic ruthenium(II) complexes enabled oxidative C-H bond functionalizations with anilines bearing removable directing groups. The C-H/N-H bond cleavages occurred most efficiently in water as a sustainable solvent and provided general access to various bioactive indoles. Mechanistic studies provided strong support for a novel reaction manifold.

引用

页码：764 / 767

页数：4

共 49 条

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