A mini-review on Biginelli adducts with notable pharmacological properties

被引：169
|
作者：
de Fatima, Angelo [1 ]
Braga, Taniris C. [1 ]
Neto, Leonardo da S. [1 ]
Terra, Bruna S. [1 ]
Oliveira, Breno G. F. [1 ]
da Silva, Daniel L. [1 ]
Modolo, Luzia V. [2 ]
机构：
[1] Univ Fed Minas Gerais, Inst Ciencias Exatas, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bot, BR-31270901 Belo Horizonte, MG, Brazil
来源：
JOURNAL OF ADVANCED RESEARCH | 2015年 / 6卷 / 03期
关键词：
Biginelli adducts; Antiproliferative activity cancer; Calcium channel; Antimicrobial activity; Antioxidants; CALCIUM-CHANNEL BLOCKERS; ACID-ESTERS; POTENT MIMICS; SOLVENT-FREE; DERIVATIVES; DIHYDROPYRIMIDINES; ANTICANCER; CATALYST;
D O I：
10.1016/j.jare.2014.10.006
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities. This mini-review describes over 100 Biginelli adducts demonstrated to be promising anticancer, inhibitors of calcium channel, anti-inflammatory, antimicrobial and antioxidant agents. Thus, this compilation presents the most notable in vitro and in vivo results for such fascinating class of organic compounds. (C) 2014 Production and hosting by Elsevier B.V. on behalf of Cairo University.
引用
收藏
页码：363 / 373
页数：11
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