Short report:: Inhibitory effect of lactoferrin on in vitro growth of Babesia caballi

被引：18
|
作者：
Ikadai, H [1 ]
Tanaka, T
Shibahara, N
Tanaka, H
Matsuu, A
Kudo, N
Shimazaki, K
Igarashi, I
Oyamada, T
机构：
[1] Kitasato Univ, Sch Vet Med & Anim Sci, Dept Vet Parasitol, Towada, Aomori 0348628, Japan
[2] Kitasato Univ, Sch Vet Med & Anim Sci, Dept Small Anim Med, Towada, Aomori 0348628, Japan
[3] Hokkaido Univ, Grad Sch Agr, Dairy Sci Lab, Sapporo, Hokkaido 0608589, Japan
[4] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido 0808555, Japan
来源：
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2005年 / 73卷 / 04期
关键词：
D O I：
10.4269/ajtmh.2005.73.710
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Lactoferrin (LF) is an important biologic molecule with many functions, one of which is antimicrobial defense. We evaluated the growth-inhibiting effects of four types of LF (native LF, Fe+3-bound [holo] LF, Fe+3-free [apo] LF, and LF hydrolyzate) on the in vitro growth of Babesia caballi and B. equi. The growth of B. caballi was significantly suppressed in media containing apo LF, but was not inhibited in media containing native LF, holo LF, or LF hydrolyzate. The growth of B. equi was not inhibited by media containing native LF, holo LF, or apo LF. These data indicate that apo LF had the strongest inhibitory effect on B. caballi. This may have been caused by inactivation or inhibition of a growth factor in the culture medium.
引用
收藏
页码：710 / 712
页数：3
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