Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis

被引：17

作者：

Zaki, Syed Ahmed ^{[1
]}

Lad, Vijay ^{[1
]}

机构：

[1] Lokmanya Tilak Municipal Gen Hosp & Med Coll, Dept Pediat, Bombay 400022, Maharashtra, India

来源：

INDIAN JOURNAL OF PHARMACOLOGY | 2011年 / 43卷 / 05期

关键词：

Hypokalemia; metabolic alkalosis; penicillin; piperacillin-tazobactam;

D O I：

10.4103/0253-7613.84986

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Piperacillin/tazobactam is a commonly prescribed antibiotic and is generally considered safe. We report a case of a 2-year-old girl who developed hypokalemic metabolic alkalosis and bradycardia after receiving intravenous piperacillin-tazobactam for bronchopneumonia. Upon withdrawal of the drug, serum potassium normalized in 2 days. Hypokalemia is a serious adverse effect of piperacillin-tazobactam and should be suspected while treating patients with this drug. Early recognition and prompt withdrawal of the drug will result in lesser morbidity.

引用

页码：609 / 610

页数：2

共 7 条

[1] Adverse drug reactions: definitions, diagnosis, and management
Edwards, IR
Aronson, JK
[J]. LANCET, 2000, 356 (9237) : 1255 - 1259
[2] Greenbaum LA, 2008, NELSON TXB PEDIAT, P267
[3] Severe hypokalaemia caused by flucloxacillin
Hoorn, Ewout J.
Zietse, Robert
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 61 (06) : 1396 - 1398
[4] Hussain S, 2010, JCPSP-J COLL PHYSICI, V20, P419, DOI 06.2010/JCPSP.419420
[5] Khan F, 2009, INDIAN J PHARM, V37, P192, DOI 10.4103/0253-7613.16222
[6] Kumar Ashish, 2003, BMC Clin Pharmacol, V3, P2, DOI 10.1186/1472-6904-3-2
[7] Piperacillin tazobactam - An updated review of its use in the treatment of bacterial infections
Perry, CM
Markham, A
[J]. DRUGS, 1999, 57 (05) : 805 - 843

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