Diet and Atherosclerosis in Apolipoprotein E-Deficient Mice

被引：26

作者：

Imaizumi, Katsumi ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Agr, Fukuoka 8128581, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2011年 / 75卷 / 06期

关键词：

apolipoprotein E-deficient mice; diet; cholesterol; inflammation; atherosclerosis; E-KNOCKOUT MICE; MONOCYTE CHEMOATTRACTANT PROTEIN-1; E-KO MICE; ENDOTHELIAL NITRIC-OXIDE; SERUM-CHOLESTEROL LEVEL; ISCHEMIC-HEART-DISEASE; LDL RECEPTOR-DEFICIENT; OXIDIZED FATTY-ACIDS; B SCAVENGER RECEPTOR; LIVER-X-RECEPTORS;

D O I：

10.1271/bbb.110059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerosis is a multifactorial, long-lasting process in humans. Accordingly, animal models in which more rapid changes occur can be useful for the study of this process. Among such models are apolipoprotein E-deficient (apoE-/-) mice, which give insight into the human process. ApoE-/- mice show impaired clearing of plasma lipoproteins and develop atherosclerosis in a short time, and hence they are an excellent model in which to assess the impact of dietary factors. This review considers lipid metabolism and inflammation as well as nutritional constituents affecting atherosclerosis, with reference to apoE-/- mice, and discusses the mechanisms through which they act.

引用

页码：1023 / 1035

页数：13

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