Kidney Disease and the Nexus of Chronic Kidney Disease and Acute Kidney Injury The Role of Novel Biomarkers as Early and Accurate Diagnostics

被引：58
作者：
Yerramilli, Murthy [1 ]
Farace, Giosi [1 ]
Quinn, John [1 ]
Yerramilli, Maha [1 ]
机构：
[1] IDEXX Labs, Res & Dev, 1 IDEXX Dr, Westbrook, ME 04092 USA
来源：
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE | 2016年 / 46卷 / 06期
关键词：
Biomarkers; Kidney; Renal; SDMA; CKD; AKI; Diagnostics; GELATINASE-ASSOCIATED LIPOCALIN; GLOMERULAR-FILTRATION-RATE; SYMMETRIC SDMA DIMETHYLARGININE; PROGRESSIVE MYOCLONUS EPILEPSY; CYSTEINE PROTEINASE-INHIBITORS; ACUTE-RENAL-FAILURE; SERUM CONCENTRATIONS; ASYMMETRIC DIMETHYLARGININE; APOLIPOPROTEIN-J; CREATININE CONCENTRATIONS;
D O I：
10.1016/j.cvsm.2016.06.011
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Chronic kidney disease (CKD) and acute kidney injury (AKI) are interconnected and the presence of one is a risk for the other. CKD is an important predictor of AKI after exposure to nephrotoxic drugs or major surgery, whereas persistent or repetitive injury could result in the progression of CKD. This brings new perspectives to the diagnosis and monitoring of kidney diseases highlighting the need for a panel of kidney-specific biomarkers that reflect functional as well as structural damage and recovery, predict potential risk and provide prognosis. This article discusses the kidney-specific biomarkers, symmetric dimethylarginine (SDMA), clusterin, cystatin B, and inosine.
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页码：961 / +
页数：34
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