Precuneal activity during encoding in veterans with posttraumatic stress disorder

被引：31

作者：

Geuze, Elbert ^{[1
]}

Vermetten, Eric ^{[1
]}

de Kloet, Carien S. ^{[1
]}

Westenberg, Herman G. M.

机构：

[1] Minist Def, Cent Mil Hosp, Dept Mil Psychiat, Utrecht, Netherlands

来源：

STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES | 2007年 / 167卷

关键词：

PTSD; memory; fMRI; precuneus; encoding;

D O I：

10.1016/S0079-6123(07)67026-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Impaired attention and memory are symptoms frequently associated with posttraumatic stress disorder (PTSD). Previous studies have identified fronto-temporal alterations during encoding in patients with PTSD. We examine the role of the precuneus (located in the posteromedial parietal lobe) that is known to play a role in memory, but has largely been neglected in PTSD research. Male veterans with and without PTSD (n = 12 per group) were subjected to fMRI during encoding of 12 neutral, non-trauma related word pairs. The precuneus was less activated in veterans with PTSD, which correlated significantly with the severity of PTSD. Like fronto-temporal regions the precuneus is differentially activated during memory formation in veterans with PTSD.

引用

页码：293 / 297

页数：5

共 16 条

[1] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[2]

BLAKE DD, 1995, J TRAUMA STRESS, V8, P75, DOI 10.1002/jts.2490080106

[3] Linear systems analysis of functional magnetic resonance imaging in human V1 [J].

Boynton, GM ;

Engel, SA ;

Glover, GH ;

Heeger, DJ .

JOURNAL OF NEUROSCIENCE, 1996, 16 (13) :4207-4221

[4] The precuneus: a review of its functional anatomy and behavioural correlates [J].

Cavanna, AE ;

Trimble, MR .

BRAIN, 2006, 129 :564-583

[5]

First M. B., 2015, User's guide for the SCID-5-PD (Structured Clinical Interview for DSM-5 Personality Disorder)

[6] Precuneus is involved in allocentric spatial location encoding and recognition [J].

Frings, Lars ;

Wagner, Kathrin ;

Quiske, Ansgar ;

Schwarzwald, Ralf ;

Spreer, Joachim ;

Halsband, Ulrike ;

Schulze-Bonhage, Andreas .

EXPERIMENTAL BRAIN RESEARCH, 2006, 173 (04) :661-672

[7] Thresholding of statistical maps in functional neuroimaging using the false discovery rate [J].

Genovese, CR ;

Lazar, NA ;

Nichols, T .

NEUROIMAGE, 2002, 15 (04) :870-878

[8]

GEUZE E, 2007, J PSYCHIAT RES 0813

[9] Neural substrates of the performance of an auditory verbal memory: between-subjects analysis by fMRI [J].

Ino, T ;

Doi, T ;

Kimura, T ;

Ito, J ;

Fukuyama, H .

BRAIN RESEARCH BULLETIN, 2004, 64 (02) :115-126

[10] Brain activation during script-driven imagery induced dissociative responses in PTSD: A functional magnetic resonance imaging investigation [J].

Lanius, RA ;

Williamson, PC ;

Boksman, K ;

Densmore, M ;

Gupta, M ;

Neufeld, RWJ ;

Gati, JS ;

Menon, RS .

BIOLOGICAL PSYCHIATRY, 2002, 52 (04) :305-311

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