Background: Acute toxoplasmosis in pregnant women presents a high risk of Toxoplasma transmission to the fetus. Early diagnosis is difficult, especially when serological testing for IgG/IgM antibodies fail to differentiate between a recent and a past infection. In this case, we rely on IgG avidity or PCR assays. Objectives: The aim of this study was to compare conventional ELISA and IgG avidity, with PCR using B1 and P30 primers for the early diagnosis of toxoplasmosis in pregnant women. Methods: Sera were collected from 143 pregnant women and measured by ELISA for anti-Toxoplasma IgG, IgM, IgA and IgG avidity. DNA was extracted from 57 peripheral blood and 14 amniotic fluid samples for PCR amplification. Results: A total of 57 out 143 women were seropositive: 30 (52.6%) were IgG+/IgM-and 27 (43.8%) were IgG+/IgM+; IgA antibodies were positive in 7 (12.2%) cases. IgG avidity was low in 9 women suggesting an acute infection; 3 women presented an intermediate avidity. PCR detected Toxoplasma DNA in 9 women presenting low avidity and was negative for the intermediate avidity cases. Conclusion: PCR combined to avidity IgG performed better than ELISA IgG, IgM and/or IgA assays alone. PCR was useful in the case of intermediate avidity.
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页码:647 / 656
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[1]
Bastien P, 2002, T R SOC TROP MED HYG, V96, P205
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Univ Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, FranceUniv Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, France
Delhaes, Laurence
Yera, Helene
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Univ Paris 05, Hop Cochin, AP HP, Parasitol Mycol Lab, Paris, FranceUniv Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, France
Yera, Helene
Ache, Sandrine
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Univ Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, FranceUniv Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, France
Ache, Sandrine
Tsatsaris, Vassili
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Univ Paris 05, Hop Port Royal, AP HP, Dept Obstet, Paris, FranceUniv Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, France
Tsatsaris, Vassili
Houfflin-Debarge, Veronique
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Univ Lille 2, Ctr Hosp, Dept Obstet, Lille, FranceUniv Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, France
机构:
CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Flori, P.
Bellete, B.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Bellete, B.
Crampe, C.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Crampe, C.
Maudry, A.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Maudry, A.
Patural, H.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Patural, H.
Chauleur, C.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Chauleur, C.
Hafid, J.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Hafid, J.
Raberin, H.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Raberin, H.
Sung, R. Tran Manh
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
机构:
Univ Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, FranceUniv Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, France
Delhaes, Laurence
Yera, Helene
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h-index: 0
机构:
Univ Paris 05, Hop Cochin, AP HP, Parasitol Mycol Lab, Paris, FranceUniv Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, France
Yera, Helene
Ache, Sandrine
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h-index: 0
机构:
Univ Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, FranceUniv Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, France
Ache, Sandrine
Tsatsaris, Vassili
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Hop Port Royal, AP HP, Dept Obstet, Paris, FranceUniv Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, France
Tsatsaris, Vassili
Houfflin-Debarge, Veronique
论文数: 0引用数: 0
h-index: 0
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Univ Lille 2, Ctr Hosp, Dept Obstet, Lille, FranceUniv Nord France UDSL, CHRU Lille, Fac Med, Mycol Parasitol Lab,CIIL,BDEEP EA4547, Lille, France
机构:
CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Flori, P.
Bellete, B.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Bellete, B.
Crampe, C.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Crampe, C.
Maudry, A.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Maudry, A.
Patural, H.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Patural, H.
Chauleur, C.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Chauleur, C.
Hafid, J.
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CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Hafid, J.
Raberin, H.
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h-index: 0
机构:
CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France
Raberin, H.
Sung, R. Tran Manh
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h-index: 0
机构:
CHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, FranceCHU St Etienne, Hop Nord, Lab Parasitol & Mycol, F-42055 St Etienne, France