Life, death, and autophagy in cancer: NF-κB turns up everywhere

被引：265

作者：

Verzella, Daniela ^{[1
]}

Pescatore, Alessandra ^{[2
]}

Capece, Daria ^{[1
,3
]}

Vecchiotti, Davide ^{[1
]}

Ursini, Matilde Valeria ^{[2
]}

Franzoso, Guido ^{[3
]}

Alesse, Edoardo ^{[1
]}

Zazzeroni, Francesca ^{[1
]}

机构：

[1] Univ Aquila, Dept Biotechnol & Appl Clin Sci DISCAB, I-67100 Laquila, Italy

[2] CNR, IGB, Inst Genet & Biophys Adriano Buzzati Traverso, I-80131 Naples, Italy

[3] Imperial Coll London, Dept Immunol & Inflammat, Ctr Mol Immunol & Inflammat, London W12 0NN, England

来源：

CELL DEATH & DISEASE | 2020年 / 11卷 / 03期

基金：

英国医学研究理事会;

关键词：

TUMOR-NECROSIS-FACTOR; PROGRAMMED CELL-DEATH; DOMAIN-LIKE PROTEIN; TNF-ALPHA; IKK-BETA; ADENOCARCINOMA CELLS; INDUCED APOPTOSIS; PROSTATE-CANCER; DOWN-REGULATION; UP-REGULATION;

D O I：

10.1038/s41419-020-2399-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Escaping programmed cell death is a hallmark of cancer. NF-kappa B transcription factors are key regulator of cell survival and aberrant NF-kappa B signaling has been involved in the pathogenesis of most human malignancies. Although NF-kappa B is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-kappa B. This review discusses how the reciprocal regulation of NF-kappa B, autophagy and programmed cell death affect cancer development and progression.

引用

页数：14

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