Synthesis, characterization and DNA interaction of copper (II) complexes with Schiff base ligands derived from 2-pyridinecarboxaldehyde and polyamines

被引：30
作者：
Yang, Xin-Bin [1 ]
Huang, Yu [2 ]
Zhang, Jin-Sheng [3 ]
Yuan, Shu-Kai [1 ]
Zeng, Ren-Quan [1 ]
机构：
[1] Southwest Univ, Dept Basic Sci, Chongqing 402460, Peoples R China
[2] Ningxia Med Univ, Coll Pharm, Yinchuan 750004, Peoples R China
[3] Guizhou Normal Univ, Sch Chem & Mat Sci, Guiyang 550001, Peoples R China
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2010年 / 13卷 / 12期
关键词：
Schiff base; Copper (II) complexes; DNA binding; DNA cleavage; CRYSTAL-STRUCTURE; CLEAVAGE ACTIVITIES; BINDING;
D O I：
10.1016/j.inoche.2010.08.006
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of copper (II) complexes a-d with Schiff bases ligands derived from the condensation reactions between 2-pyridinecarboxaldehyde and different polyamines (ethylenediamine, diethylenetriamine, triethylenetetramine and tetraethylenepentamine) were synthesized and characterized by elemental analysis. FT-IR spectroscopy, HRMS, molar conductance and molecular modeling studies. The interactions of the copper complexes a-d with DNA were investigated by the UV spectra, viscosity measurements and gel electrophoresis under physiological conditions. The experimental results indicated that four complexes could bind to DNA via an intercalative mode and showed a different DNA cleavage activity with the sequence: d>c>a>b. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：1421 / 1424
页数：4
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