Fat Graft in Surgical Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ)

被引：2

作者：

De Cicco, Davide ^{[1
]}

Tartaro, Gianpaolo ^{[2
]}

Colella, Giuseppe ^{[2
]}

Dell'Aversana Orabona, Giovanni ^{[1
]}

Santagata, Mario ^{[2
]}

Ferrieri, Ivo ^{[2
]}

Troiano, Antonio ^{[1
]}

Stagliano, Samuel ^{[2
]}

Volgare, Andrea Salvatore ^{[3
]}

D'Amato, Salvatore ^{[2
]}

机构：

[1] Univ Naples Federico II, Dept Neurosci Reprod & Odontostomatol Sci, I-80138 Naples, Italy

[2] Univ Campania Luigi Vanvitelli, Dept Multidisciplinary Med Surg & Dent Specialtie, I-80138 Naples, Italy

[3] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy

来源：

APPLIED SCIENCES-BASEL | 2021年 / 11卷 / 23期

关键词：

medication-related osteonecrosis of the jaws; MRONJ; BRONJ; fat graft; adipose tissue graft; adipose-derived stem cells; adipose-derived stromal cells; ASC; ASCs; mesenchymal stem cells; BISPHOSPHONATE-RELATED OSTEONECROSIS; HUMAN ADIPOSE-TISSUE; SURGEONS POSITION PAPER; MESENCHYMAL STEM-CELLS; AMERICAN ASSOCIATION; HYPERBARIC-OXYGEN; EFFICACY; THERAPY; BONE; DEBRIDEMENT;

D O I：

10.3390/app112311195

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Background: Although the published literature has grown exponentially during the last few decades, managing medication-related osteonecrosis of the jaws (MRONJ) remains challenging. Since the first description of adipose-derived stem cells, cell therapy showed promising perspectives in surgical treatment of MRONJ. In this study, the beneficial effect of fat graft in surgical treatment of stage 2 and 3 MRONJ patients was assessed. Methods: A retrospective analysis of the evolution pattern of the disease was conducted comparing the outcomes of MRONJ patients who underwent sequestrectomy followed by fat graft (n = 9) and those who received sequestrectomy alone (n = 12). Results: Improvement of the disease stage was observed in 77.8% vs. 22.2% cases in group A and B, respectively (p = 0.030); disease stability was documented in 11.1% vs. 25.0% cases in group A and B, respectively (p = 0.603); worsening of MRONJ stage was observed in 11.1% vs. 50.0% cases in group A and B, respectively (p = 0.159). Conclusions: Despite the small sample size, this study suggests that fat graft may represent a promising low-risk and cost-efficient adjunctive therapy in the surgical treatment of MRONJ patients.

引用

页数：15

共 75 条

[1] American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws [J].