Participation of interferon-alpha in regulation of apoptosis

被引：3
作者：
Bazhanova, ED [1 ]
机构：
[1] Russian Acad Sci, IM Sechenov Evolutionary Physiol & Biochem Inst, St Petersburg 196140, Russia
来源：
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY | 2005年 / 41卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
D O I：
10.1007/s10893-005-0045-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
According to current data, endocrine system is closely related to immune system and interferons play an important role in this relationship. Interferons can inhibit cell proliferation or control apoptosis. Interferon-alpha (IA) produces a stimulatory effect on DNA sites controlling, via JAK/STAT-pathway, production of anti-apoptotic proteins of the Bcl-2 family. Besides, a very important property of IA is its ability to arrest the cell in the G1-G0 phase, which is what determines static effect of IA on growth of many tumors. Later, in these cells, either apoptosis can develop or they can survive. This depends on many factors including physiological state of the tissue and cell, its differentiation, stage of cellular cycle, etc.
引用
收藏
页码：127 / 133
页数：7
相关论文
共 70 条
[1]   Poly(A) polymerase specifically implicated in the mechanism of chemotherapeutic drug action during cell apoptosis [J].
Atabasides, H ;
Tsiapalis, CM ;
Havredaki, M .
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 2000, 15 (01) :10-14
[2]  
Bainbridge DRJ, 1999, J REPROD FERTIL, V116, P305, DOI 10.1530/jrf.0.1160305
[3]   The combination of apoptotic U937 cells and lupus IgG is a potent IFN-α inducer [J].
Båve, U ;
Alm, GV ;
Rönnblom, L .
JOURNAL OF IMMUNOLOGY, 2000, 165 (06) :3519-3526
[4]   Evidence against a direct cytotoxic effect of alpha interferon and zidovudine in HTLV-I associated adult T cell leukemia/lymphoma [J].
Bazarbachi, A ;
Nasr, R ;
El-Sabban, ME ;
Mahé, A ;
Mahieux, R ;
Gessain, A ;
Darwiche, N ;
Dbaibo, G ;
Kersual, J ;
Zermati, Y ;
Dianoux, L ;
Chelbi-Alix, MK ;
de Thé, H ;
Hermine, O .
LEUKEMIA, 2000, 14 (04) :716-721
[5]   Measurements of catecholamine-mediated apoptosis of immunocompetent cells by capillary electrophoresis [J].
Bergquist, J ;
Josefsson, E ;
Tarkowski, A ;
Ekman, R ;
Ewing, A .
ELECTROPHORESIS, 1997, 18 (10) :1760-1766
[6]   Autoimmunity against pancreatic islets and other tissues before and after interferon-α therapy in patients with hepatitis C virus chronic infection [J].
Betterle, C ;
Fabris, P ;
Zanchetta, R ;
Pedini, B ;
Tositti, G ;
Bosi, E ;
de Lalla, F .
DIABETES CARE, 2000, 23 (08) :1177-1181
[7]  
Bodey B, 1997, IN VIVO, V11, P351
[8]   Age-related death-survival balance in myocardium: an immunohistochemical and biochemical study [J].
Centurione, L ;
Antonucci, A ;
Miscia, S ;
Grilli, A ;
Rapino, M ;
Grifone, G ;
Di Giacomo, V ;
Di Giulio, C ;
Falconi, M ;
Cataldi, A .
MECHANISMS OF AGEING AND DEVELOPMENT, 2002, 123 (04) :341-350
[9]   Acute effects of interferon-α administration on testosterone concentrations in healthy men [J].
Corssmit, EPM ;
Endert, E ;
Sauerwein, HP ;
Romijn, JA .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2000, 143 (03) :371-374
[10]   Biologic responses to IFN-α administration in humans [J].
Corssmit, EPM ;
De Metz, J ;
Sauerwein, HP ;
Romijn, JA .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2000, 20 (12) :1039-1047
1234567