Out-of-clinic measurement of sweat chloride using a wearable sensor during low-intensity exercise

被引:19
作者
Choi, Dong-Hoon [1 ]
Kitchen, Grant B. [1 ]
Jennings, Mark T. [2 ]
Cutting, Garry R. [3 ]
Searson, Peter C. [1 ,4 ]
机构
[1] Johns Hopkins Univ, Inst Nanobiotechnol, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ Hosp, Div Pulm & Crit Care, Dept Med, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Inst Genet Med, Baltimore, MD USA
[4] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA
关键词
BIOLOGICAL VARIATION;
D O I
10.1038/s41746-020-0257-z
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Wearable sensors have the potential to enable measurement of sweat chloride outside the clinic. Here we assess the feasibility of mild exercise as an alternative to pilocarpine iontophoresis for sweat generation. The results from this proof-of-concept study suggest that mild exercise could be a feasible approach to obtain reliable measurements of sweat chloride concentration within 20-30 min using a wearable sensor.
引用
收藏
页数:4
相关论文
共 11 条
[1]   Normal walking speed: a descriptive meta-analysis [J].
Bohannon, Richard W. ;
Andrews, A. Williams .
PHYSIOTHERAPY, 2011, 97 (03) :182-189
[2]   Two Distinct Types of Sweat Profile in Healthy Subjects While Exercising at Constant Power Output Measured by a Wearable Sweat Sensor [J].
Choi, Dong-Hoon ;
Kitchen, Grant ;
Kim, Ji Soo ;
Li, Yi ;
Kim, Kain ;
Jeong, In Cheol ;
Jane Nguyen ;
Stewart, Kerry J. ;
Zeger, Scott L. ;
Searson, Peter C. .
SCIENTIFIC REPORTS, 2019, 9 (1)
[3]  
Choi Dong-Hoon, 2018, J Cyst Fibros, V17, pe35, DOI 10.1016/j.jcf.2018.03.005
[4]   A wearable potentiometric sensor with integrated salt bridge for sweat chloride measurement [J].
Choi, Dong-Hoon ;
Li, Yi ;
Cutting, Garry R. ;
Searson, Peter C. .
SENSORS AND ACTUATORS B-CHEMICAL, 2017, 250 :673-678
[5]   Effects of Exercise on Respiratory Flow and Sputum Properties in Patients With Cystic Fibrosis [J].
Dwyer, Tiffany J. ;
Alison, Jennifer A. ;
McKeough, Zoe J. ;
Daviskas, Evengelia ;
Bye, Peter T. P. .
CHEST, 2011, 139 (04) :870-877
[6]   Analytical and biological variation in repeated sweat chloride concentrations in clinical trials for CFTR modulator therapy [J].
LeGrys, V. A. ;
Moon, T. C. ;
Laux, J. ;
Rock, M. J. ;
Accurso, F. .
JOURNAL OF CYSTIC FIBROSIS, 2018, 17 (01) :43-49
[7]   Diagnostic sweat testing: The cystic fibrosis foundation guidelines [J].
LeGrys, Vicky A. ;
Yankaskas, James R. ;
Quittell, Lynne M. ;
Marshall, Bruce C. ;
Mcgayzel, Peter J., Jr. .
JOURNAL OF PEDIATRICS, 2007, 151 (01) :85-89
[8]   Exercise improves lung function and habitual activity in children with cystic fibrosis [J].
Paranjape, Shruti M. ;
Barnes, Laura A. ;
Carson, Kathryn A. ;
von Berg, Karen ;
Loosen, Holly ;
Mogayzel, Peter J., Jr. .
JOURNAL OF CYSTIC FIBROSIS, 2012, 11 (01) :18-23
[9]   BIOLOGY OF SWEAT GLANDS AND THEIR DISORDERS .1. NORMAL SWEAT GLAND-FUNCTION [J].
SATO, K ;
KANG, WH ;
SAGA, K ;
SATO, KT .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1989, 20 (04) :537-563
[10]   Variability of sweat chloride concentration in subjects with cystic fibrosis and G551D mutations [J].
Vermeulen, F. ;
Le Camus, C. ;
Davies, J. C. ;
Bilton, D. ;
Milenkovic, D. ;
De Boeck, K. .
JOURNAL OF CYSTIC FIBROSIS, 2017, 16 (01) :36-40